Diet and Exercise Approaches for Weight Loss in Older Adults With Obesity

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 50 to 75 who have obesity (BMI 30-50 kg/m2). It tests diet and exercise programs for weight loss while keeping muscle.

Age

50 to 75 years

Sex

Men and women. Women must have been postmenopausal for at least 1 year.

Disease stage

Obesity with a BMI of 30-50 kg/m2.

Earlier treatment

People who use other medicines that affect body weight or appetite must have used them in a stable way for at least 3 months.

Main reasons for not taking part

• Weight over 450 pounds (204 kg)
• Sarcopenia, now or diagnosed before
• Existing kidney disease
• Current binge eating disorder, anorexia or bulimia
• Untreated thyroid problems, cancer (except basal cell), or gut disorders that affect eating or nutrient absorption

The registry criteria, word for word

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

• Are you between 50 and 75 years old?YesNo

What the trial wants to find out

To test adaptive intensive behavioral therapy strategies comprising dietary patterns with varying amounts of protein and including supplemental protein or resistance exercise training for promoting weight loss and attenuating lean mass loss in adults aged 50-75 with obesity.

The 6 groups in the trial

• High Protein Diet OnlyExisting treatment, for comparison

  Enrollment in State of Slim (SOS) weight loss program with a high protein diet. This arm includes participants identified as responders to the high protein diet counseling in stage 1 at the week 8 assessment.

  Treatment: High Protein Diet Counceling

• High Protein Diet + SupplementExisting treatment, for comparison

  Enrollment in State of Slim (SOS) weight loss program with a high protein diet. Participants identified as non-responders at the week 8 assessment will receive protein supplements to augment their intervention plan.

  Treatment: High Protein Diet Counceling and Protein Supplement

• High Protein Diet + Supervised ExerciseExisting treatment, for comparison

  Enrollment in State of Slim (SOS) weight loss program with a high protein diet. Participants identified as non-responders at the week 8 assessment will receive supervised resistance training sessions to augment their intervention plan.

  Treatment: High Protein Diet Counceling and Supervised Exercise

• Standard Protein Diet OnlyExisting treatment, for comparison

  Enrollment in State of Slim (SOS) weight loss program with a standard protein diet. This arm includes participants identified as responders to the standard protein diet counseling in stage 1 at the week 8 assessment.

  Treatment: Standard Protein Diet Counceling

• Standard Protein Diet + SupplementExisting treatment, for comparison

  Enrollment in State of Slim (SOS) weight loss program with a standard protein diet. Participants identified as non-responders at the week 8 assessment will receive protein supplements to augment their intervention plan.

  Treatment: Standard Protein Diet Counceling and Protein Supplement

• Standard Protein Diet + Supervised ExerciseExisting treatment, for comparison

  Enrollment in State of Slim (SOS) weight loss program with a standard protein diet. Participants identified as non-responders at the week 8 assessment will receive supervised resistance training sessions to augment their intervention plan.

  Treatment: Standard Protein Diet Counceling and Supervised Exercise