Measuring Kidney Function With Iohexol in Advanced Chronic Kidney Disease
Compares iohexol blood tests with usual ways of measuring kidney function in advanced kidney disease.
Plain-language title generated from the registry record
Registry title: The Practicality and Utility of Measured vs Estimated GFR in adCKD
Key facts
- Where
- Manchester, United KingdomSee the site
Where in United Kingdom
- Manchester Royal InfirmaryManchester, United KingdomNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Manchester University NHS Foundation Trust
- Trial code
- NCT07450534
- Record updated
- 4 March 2026
- Original description
The goal of this observational study is to assess if new ways of measuring kidney function can better predict when individuals will become symptomatic due to kidney failure, and whether residual kidney function can be accurately measured in those already on dialysis.Read full original descriptionShow less
The Practicality & Utility of Estimated vs Measured Renal Function in Advanced Kidney Disease, Whether Treated With Dialysis or Not: Can Better Techniques be Used to Predict the Onset of the Uraemic Syndrome and Guide Dialysis Requirements
The goal of this observational study is to assess if new ways of measuring kidney function can better predict when individuals will become symptomatic due to kidney failure, and whether residual kidney function can be accurately measured in those already on dialysis.
The main questions the study is trying to answer is whether measuring kidney function by clearance of iohexol is comparable to the current standard of care methods.
In addition to routine care, participants will:
* undergo a brief clinical assessment * be given an injection of iohexol and asked to perform 4 finger prick blood tests over 24 hours, recording the time of each sample. Samples will be returned in person or posted back * be asked to complete a questionnaire on their experience
Inclusion: Adults (18 year s or older); Able to give informed consent; Progressive chronic kidney disease predicted to start renal replacement therapy in the next 6 months OR established on dialysis (either haemodialysis or peritoneal) with residual renal function (Urine output >100ml/day).
Exclusion: Pre-dialysis and planned renal transplant within 1 month; Known allergy to iodinated contrast media; Under 18 years; Unable to perform fingerprick blood testing; Unable to comply with urine collection; Unable or unwilling to give informed consent in English; Acute kidney injury expected to recover renal function; Pregnant or breast feeding; Significant fluid overload (significant peripheral oedema or ascites AND >10kg above estimated dry weight).