FET PET/CT Imaging To Localize Pituitary Adenomas In Cushing Disease

Who can take part

• Patients must meet ALL criteria listed below for entry:
• Biochemically diagnosed ACTH-dependent Cushing disease
• No previous pituitary surgery
• Planned to undergo pituitary surgery for localization/resection of adenoma
• No contraindications for PET/CT
• Recent (within 3 months) pituitary MR, or pending pituitary MR to be performed as close as possible to FET PET/CT
• Age ≥ 18 years
• Ability to provide informed consent

Who cannot take part

• Need for emergent surgery that would be delayed by participation
• Patients receiving any other investigational agent within the past 28 days
• Bacterial, viral, or fungal infections requiring systemic therapy
• Serious co-morbidities and serious nonmalignant disease (e.g., hydronephrosis, kidney failure, liver failure, systemic or local inflammatory or autoimmune diseases or other conditions) that in the opinion of the investigator could compromise patient safety and/or protocol objectives
• Known diagnosis of autoimmune disorders
• Known hypersensitivity to any excipients used in FET
• Pregnant as determined by a pregnancy test as per institutional guidelines for individuals of child-bearing potential
• Declining to use effective contraceptive methods during the study (for individuals of child-bearing potential)
• Breastfeeding. Note: nursing parents are allowed if the potential participant commits to pumping breast milk and discarding it from injection to ≥ 24 hours from the time of the FET injection