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Physical Activity and Heart Outcomes in People With Long-Term Heart Failure

Follows how active adults with chronic heart failure are and how they fare.

Plain-language title generated from the registry record
Registry title: Assessment of Physical Activity and Cardiovascular Outcomes in Patients With Chronic Heart Failure

Key facts

Where
Munich, GermanySee the site

Where in Germany

  • LMU University HospitalMunich, GermanyTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
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Trial details

Who runs it
LMU Klinikum
Trial code
NCT07460531
Record updated
11 March 2026
Original description
SOPHIE is a prospective, multicentre, observational cohort study aiming to enrol 2,000 CHF patients. Baseline assessments include validated PA questionnaires (GPAQ, IPAQ, KCCQ) and seven-day step counts from commercially available pedometer devices. Follow-up is conducted every six months via telephone, repeating PA assessments and recording cardiovascular events, hospitalisations, and patient-reported outcomes.Read full original descriptionShow less

Assessment of Physical Activity and Cardiovascular Outcomes in Patients With Chronic Heart Failure

SOPHIE is a prospective, multicentre, observational cohort study aiming to enrol 2,000 CHF patients. Baseline assessments include validated PA questionnaires (GPAQ, IPAQ, KCCQ) and seven-day step counts from commercially available pedometer devices. Follow-up is conducted every six months via telephone, repeating PA assessments and recording cardiovascular events, hospitalisations, and patient-reported outcomes.

Inclusion: Heart failure NT-proBNP >600 pg/ml (at least once in the history) NYHA-Class II-IV HFrEF - heart failure with reduced ejection fraction; LVEF ≤40% or HFmrEF - heart failure with mildly reduced ejection fraction; LVEF 41% - 49% or HFpEF - heart failure with preserved ejection fraction; LVEF ≥50%; Age ≥18 years old; Willingness to participate in the study, confirmed by a signed informed consent form; Ownership of a pedometer (e.g. smartwatch, activity tracker, smartphone-app, analogical pedometer).

Exclusion: Disease or disability that prevents physical activity; Hospitalisation due to heart failure within the last three months.

ClinicalTrials.gov NCT07460531