Thyroid nodules and thyroid cancer in people who had radiotherapy for childhood cancer
Follows young people given radiotherapy to learn about thyroid nodules and thyroid cancer.
Plain-language title generated from the registry record
Registry title: Thyroid Carcinoma in Cancer Patients Undergoing Radiotherapy
Key facts
- Where
- Bologna, ItalySee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 10 and 43 years old?
Source: NCT07473518, who can take part
Where in Italy
- UO Medicina Nucleare - IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna, ItalyTaking people
- UOC Pediatria - IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Trial code
- NCT07473518
- Record updated
- 16 March 2026
- Original description
This study aims to define the optimal surveillance strategy for children exposed to radiotherapy by assessing the incidence, risk factors, and timing of thyroid nodules and differentiated thyroid cancer. It also investigates the genetic features of thyroid tumors in this population to identify predictive biomarkers of onset, malignancy, and aggressiveness. Ultimately, the goal is to support more personalized management, including tailored surgery and targeted therapies.Read full original descriptionShow less
Thyroid Carcinoma in Cancer Patients Undergoing Radiotherapy
This study aims to define the optimal surveillance strategy for children exposed to radiotherapy by assessing the incidence, risk factors, and timing of thyroid nodules and differentiated thyroid cancer. It also investigates the genetic features of thyroid tumors in this population to identify predictive biomarkers of onset, malignancy, and aggressiveness. Ultimately, the goal is to support more personalized management, including tailored surgery and targeted therapies.
Inclusion: For the group of oncologic patients who underwent radiotherapy:; Radiotherapy for an oncologic condition performed between January 1, 1999, and December 31, 2018; Age at the time of radiotherapy < 18 years; Follow-up of at least 4 years conducted at the Endocrine-Metabolic Diseases Program, Pediatric Unit, IRCCS AOU Bologna; Obtained informed consent; For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC:; No history of exposure to ionizing radiation; No specific risk factors for DTC (autoimmune thyroiditis, familial forms, genetic syndromes); Thyroid ultrasound performed between January 1, 1999, and December 31, 2018, at the Nuclear Medicine Unit of IRCCS AOU Bologna; Age at the time of the thyroid ultrasound < 18 years; Obtained informed consent.
Exclusion: For the group of oncologic patients who underwent radiotherapy:; Patients transferred to another center before completing 4 years of follow-up after radiotherapy at the Pediatric Unit of IRCCS AOU Bologna, without having received a diagnosis of thyroid cancer; For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC:; None.