Thyroid nodules and thyroid cancer in people who had radiotherapy for childhood cancer
Follows young people given radiotherapy to learn about thyroid nodules and thyroid cancer.
Plain-language title generated from the registry record
Registry title: Thyroid Carcinoma in Cancer Patients Undergoing Radiotherapy
Key facts
- Where
- Bologna, ItalySee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people who had radiotherapy for cancer before age 18, between 1999 and 2018. It also includes a comparison group who never had radiation.
- Age
- 10 to 43 years. Radiotherapy group: under 18 at the time of radiotherapy. Comparison group: under 18 at the time of the thyroid ultrasound.
- Sex
- All sexes can join.
- Disease stage
- Radiotherapy group: any cancer treated with radiotherapy. Comparison group: no thyroid cancer risk factors named in the record.
- Earlier treatment
- Radiotherapy group: radiotherapy between January 1, 1999, and December 31, 2018, with at least 4 years of follow-up at the IRCCS AOU Bologna Pediatric Unit. Comparison group: no past exposure to ionizing radiation.
Main reasons for not taking part
- Radiotherapy group: moved to another center before 4 years of follow-up, without a thyroid cancer diagnosis
- Comparison group: any past exposure to ionizing radiation
- Comparison group: autoimmune thyroiditis, familial forms or genetic syndromes
- Comparison group: no thyroid ultrasound at the Nuclear Medicine Unit of IRCCS AOU Bologna between 1999 and 2018
- No informed consent
Read by machine on 13 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 10 and 43 years old?
Source: NCT07473518, who can take part
Where in Italy
- UO Medicina Nucleare - IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna, ItalyContact: Letizia CalderoniTaking people
- UOC Pediatria - IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna, ItalyContact: Federico BaronioTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Trial code
- NCT07473518
- Record updated
- 16 March 2026
- Original description
This study aims to define the optimal surveillance strategy for children exposed to radiotherapy by assessing the incidence, risk factors, and timing of thyroid nodules and differentiated thyroid cancer. It also investigates the genetic features of thyroid tumors in this population to identify predictive biomarkers of onset, malignancy, and aggressiveness. Ultimately, the goal is to support more personalized management, including tailored surgery and targeted therapies.Read full original descriptionShow less
Thyroid Carcinoma in Cancer Patients Undergoing Radiotherapy
This study aims to define the optimal surveillance strategy for children exposed to radiotherapy by assessing the incidence, risk factors, and timing of thyroid nodules and differentiated thyroid cancer. It also investigates the genetic features of thyroid tumors in this population to identify predictive biomarkers of onset, malignancy, and aggressiveness. Ultimately, the goal is to support more personalized management, including tailored surgery and targeted therapies.
Inclusion: For the group of oncologic patients who underwent radiotherapy:; Radiotherapy for an oncologic condition performed between January 1, 1999, and December 31, 2018; Age at the time of radiotherapy < 18 years; Follow-up of at least 4 years conducted at the Endocrine-Metabolic Diseases Program, Pediatric Unit, IRCCS AOU Bologna; Obtained informed consent; For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC:; No history of exposure to ionizing radiation; No specific risk factors for DTC (autoimmune thyroiditis, familial forms, genetic syndromes); Thyroid ultrasound performed between January 1, 1999, and December 31, 2018, at the Nuclear Medicine Unit of IRCCS AOU Bologna; Age at the time of the thyroid ultrasound < 18 years; Obtained informed consent.
Exclusion: For the group of oncologic patients who underwent radiotherapy:; Patients transferred to another center before completing 4 years of follow-up after radiotherapy at the Pediatric Unit of IRCCS AOU Bologna, without having received a diagnosis of thyroid cancer; For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC:; None.