Testing how exercise changes protein use in older adults with type 2 diabetes
Tests a 12-week exercise program in older adults with type 2 diabetes.
Key facts
- Who runs it
- University of Illinois at Urbana-Champaign
- Where
- Urbana, United StatesSee the site
- Trial code
- Registry title
- Exercise and Protein Efficiency in T2D
- Status
- Recruiting
- People taking part
- 30 people, planned
- Started
- 9 Feb 2026
- Expected to end
- 1 Jul 2028
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- 12 week progressive exercise training
- Record updated
- 29 April 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for older adults aged 65 or over, either with type 2 diabetes or without diabetes as a control group. They take part in a 12-week exercise training program.
- Age
- At least 65 years old
- Sex
- All sexes
- Disease stage
- Type 2 diabetes diagnosed by a physician with HbA1c >6.5% (48 mmol/mol), or a control group with normal blood sugar (HbA1c not above 5.6% (38 mmol/mol) and fasting blood glucose at or below 99 mg/dL (5.5 mmol/L)).
- Earlier treatment
- No structured exercise during the prior 6 months and stable weight for the prior 6 months.
- Biomarker or test result
- Body mass index 25-40 kg/m^2. Waist to hip ratio above 0.8 for women and above 1.0 for men.
Main reasons for not taking part
- Uncontrolled diabetes (HbA1c above 10% (86 mmol/mol) or insulin prescribed)
- Diabetic neuropathy
- Taking statins
- Untreated hypothyroidism or epilepsy
- Any illness that prevents exercise testing
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- At least 65 years old
- Body mass index: 25-40 kg/m\^2
- Female: Waist to hip ratio >0.8
- Male: Waist to hip ratio >1.0
- Free from structured exercise during the prior 6 months (mo) weight stable for the prior 6 months; T2D group:; -Diagnosed by a physician with elevated glycosylated hemoglobin (HbA1c) >6.5%; Control group:; -Normoglycemic with HbA1c levels not exceeding 5.6% and fasting blood glucose levels below or equal to 99 mg/dL (5.5mmol)
Who cannot take part
- Peripheral edema Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation
- Untreated hypothyroidism, epilepsy, medications that affect vasoactivity, possibility of pregnancy, and any neurological, cardiovascular, or musculoskeletal disease that precludes exercise testing
- Uncontrolled diabetes (evidence of HbA1c > 10%, prescription of insulin)
- Diagnoses of diabetic neuropathy or failing diabetic neuropathy screening
- Statins
Where in United States
- Freer Hall - University of IllinoisUrbana, United StatesContact: Nicholas Burd (Professor), PhDTaking people
About the trial
What the trial wants to find out
In this randomized controlled trial, 30 older adults (aged> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program. They will undergo pre- and post-testing that includes body composition measures; oral glucose tolerance testing; cardiovascular fitness and muscle performance testing; dietary protein efficiency assessed using the indicator amino acid oxidation (IAAO) method; and a gut microbiota trial. The dietary protein efficiency trial will include repeated ingestion of crystallized amino acids (drink) containing stable isotopes, urine samples, and breath samples. The gut microbiome trial will consist of a single ingestion of a Mediterranean-based modeled meal enriched with 13C-phenylalanine (in the drink) and repeated blood draws. Participants will also be asked to give a fecal sample after the gut microbiome trial.
The 2 groups in the trial
- Non-DiabeticExisting treatment, for comparison
Non-diabetic control group. Will be assigned to all pre-/post-testing and complete the 12-week intervention period.
Treatment: 12 week progressive exercise training
- Diabetic groupTreatment being tested
Diagnosed diabetic group. Will complete all pre- and post-testing and the 12-week intervention period.
Treatment: 12 week progressive exercise training
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Exercise Impact on Dietary Protein Efficiency in Older Adults With Type 2 Diabetes
- Plain-language title
- Testing how exercise changes protein use in older adults with type 2 diabetesGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 13 November 2026.
- Record updated
- 29 April 2026