Tests a rapid magnetic brain stimulation treatment for depression in adults
Compares rapid magnetic brain stimulation with sham stimulation in adults with depression.
Plain-language title generated from the registry record
Registry title: Sham-Controlled Rapid-Acting Neuromodulation for Depression
Key facts
- Where
- Sacramento, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07487454, who can take part
Where in United States
- UC Davis Medical CenterSacramento, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of California, Davis
- Trial code
- NCT07487454
- Record updated
- 16 June 2026
- Original description
The goal of this study is to learn whether 5 days of accelerated intermittent theta burst stimulation (iTBS), a rapid form of transcranial magnetic stimulation (TMS), which is a non-invasive procedure that uses magnetic fields to stimulate brain activity, works to treat depression in adults.Read full original descriptionShow less
Sham-Controlled Rapid-Acting Neuromodulation for Depression
The goal of this study is to learn whether 5 days of accelerated intermittent theta burst stimulation (iTBS), a rapid form of transcranial magnetic stimulation (TMS), which is a non-invasive procedure that uses magnetic fields to stimulate brain activity, works to treat depression in adults.
The main questions it aims to answer are:
* Does accelerated iTBS reduce depressive symptoms compared to sham (placebo) stimulation? * Are there measurable brain, biological, and digitally measured emotion changes associated with treatment response?
Participants will:
* Be randomly assigned to receive either active iTBS or sham stimulation * Receive 10 stimulation sessions per day for 5 consecutive days (total of 50 sessions) * Complete MRI brain scans and EEG recordings before and after treatment * Provide blood and saliva samples to measure biological markers * Complete depression rating scales and questionnaires at baseline, during treatment, and at follow-up visits * Use a secure mobile app to record brief facial and vocal samples during the 5-day treatment and at follow-up visits * Return for follow-up visits at 1 week and at 1, 3, 6, and 12 months after treatment
Inclusion: English speaking; Able to provide informed consent; 18-65 years old; Meets MDD criteria per the Mini International Neuropsychiatric Interview (MINI).
Exclusion: Use of benzodiazepines or medications that would interfere with TMS treatment as per PI discretion; Contraindications to receiving TMS and/or MRI as determined by screening questionnaires; Participation in any clinical study with exposure to any investigational treatment or product within the previous 30 days, or plan on concurrent participation in other studies; Unable to consent (due to medical condition, acute psychosis, substance use, etc); Active substance use or severe substance use that in the opinion of the PI would interfere with study participation; Untreated, active psychosis; Female patient who is breastfeeding, pregnant or who is planning a pregnancy during the study.