IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success

Who can take part

• Provided informed consent
• Age ≥ 40 years
• Ineligibility for or refusal of surgical management
• Moderate-severe knee pain as determined by visual analog scale > 5 out of 10
• Osteoarthritis based on X-ray. Kellgren-Lawrence score > 2 based on radiograph completed within 3 months of procedure date
• Resistant/failed some form of conservative treatment (e.g. NSAIDS/physical therapy/steroid joint injection/hyaluronic acid joint injection) for at least 3 months
• Able to comply with all treatments and protocol follow-up visits

Who cannot take part

• Prior total or partial knee replacement in the subject knee
• Presence of pacemakers, aneurysm clips, neurostimulators, or any other metal implant not compatible with PET/MRI
• History of fibromyalgia, autoimmune, or inflammatory disorder
• History of any lumbar spine surgery, spine injections, or radicular pain in the extremity believed to originate from the spine
• Allergy to iodinated contrast agents
• Active infection or malignancy
• Uncorrectable bleeding diathesis
• Mild knee pain as determined by visual analog scale < 5 out of 10
• OA on knee radiograph resulting in greater than 20 degree varus or valgus angulation
• Moderate loss of kidney function, define as estimated glomerular filtration rate of less than 45 mL/min
• Significant arterial atherosclerosis that would limit selective angiography
• Recent (within 12 months) or active cigarette use
• Active pregnancy