Long-term registry following children and teens with pulmonary hypertension
Observes children and teens with lung high blood pressure over time, under usual care.
Plain-language title generated from the registry record
Registry title: Insights Into Pediatric Pulmonary Hypertension: A Real-World Registry of Epidemiology and Outcomes
Key facts
- Where
- Guangzhou, ChinaSee the site
Where in China
- Guangdong Provincial People's HospitalGuangzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Guangdong Provincial People's Hospital
- Trial code
- NCT07495774
- Record updated
- 27 March 2026
- Original description
Pediatric pulmonary hypertension (PH) shares similarities with PH in adulthood, but specific differences still require unique approaches. Despite major advances, risk scores for pediatric PH still need to be validated, and targeted drug therapies in pediatric populations remain under-studied. Consequently, there is a great need for comprehensive real-world longitudinal data of pediatric PH.Read full original descriptionShow less
Insights Into Epidemiology, Management, and Outcomes of Pediatric Pulmonary Hypertension: The INSPIRE-PH Multicenter Real-World Registry
Pediatric pulmonary hypertension (PH) shares similarities with PH in adulthood, but specific differences still require unique approaches. Despite major advances, risk scores for pediatric PH still need to be validated, and targeted drug therapies in pediatric populations remain under-studied. Consequently, there is a great need for comprehensive real-world longitudinal data of pediatric PH.
The INSPIRE-PH registry is a multicenter, observational, real-world registry designed to systematically collect longitudinal clinical data on children and adolescents with PH. Patients enrolled in the registry receive standard clinical care determined by their treating physicians. No study-mandated interventions are imposed. Longitudinal observation of this cohort aims to provide important insights into disease progression, treatment effectiveness, and long-term prognosis in pediatric PH.
The cohort was initially established prospectively in 2006, with all cases reclassified according to the 7th World Symposium for Pulmonary Hypertension (WSPH) criteria in 2024, and new patients continue to be prospectively enrolled. The registry is supervised by the principal investigator, independently from the financial sponsors.
Inclusion: Children and adolescents aged <18 years at diagnosis; Diagnosed pulmonary hypertension (PH) according to the prevailing diagnostic criteria at the time of enrollment; Enrollment in the registry at participating centers; Provision of informed consent by patients and/or legal guardians; Availability for longitudinal follow-up.
Exclusion: Inability to confirm PH diagnosis due to insufficient clinical or hemodynamic data; Refusal or inability to provide informed consent.