Effects of Transcranial Temporal Interference Stimulation on Cognitive Function in Mild Cognitive Impairment
Key facts
- Who runs it
- Shanghai University of Sport
- Where
- China1 site in 1 countryChoose a country to see its sites
- Trial code
- NCT07519798
- CHICTR2600119709
- Status
- Completed
- People taking part
- 76 people enrolled
- Started
- 15 Apr 2026
- Ended
- 15 Aug 2026
- Type of study
- Interventional, 2 groups
- Treatments tested
- Active Temporal Interference Stimulation (TIS)
- Placebo / Sham TIS
- Record updated
- 5 November 2026
Who can take part
- Age
- 60 years to 80 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 16 criteriaShow less
Who can take part
- Age 60-80 years
- Community-dwelling
- Montreal Cognitive Assessment (MoCA) score < 26
- Clinical Dementia Rating (CDR) score = 0.5
- Activities of Daily Living (ADL) score < 26 (largely intact daily function)
- Does not meet criteria for dementia diagnosis (based on DSM-5 or NIA-AA criteria)
- No contraindications for MRI examination (no metallic implants, no claustrophobia)
- Able to provide written informed consent
Who cannot take part
- Previous deep brain stimulation or electroconvulsive therapy within 6 months
- Concurrent participation in another interventional clinical trial
- Neurological conditions that may cause cognitive decline (e.g., cerebrovascular disease, encephalitis, Parkinson's disease, Huntington's disease)
- Severe depression (Geriatric Depression Scale > 10) or other major psychiatric disorders
- History of seizures or epilepsy
- Contraindications for non-invasive brain stimulation: electronic or ferromagnetic implants, non-MRI compatible metal implants, history of seizures, pregnancy
- Severe visual, auditory, or language impairments preventing completion of neuropsychological assessments
- Alcohol or substance dependence
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
To explore the effects of transcranial temporal interference stimulation (tTIS) on cognitive function and dual-task walking performance, as well as its underlying neuroimaging mechanisms, in individuals with mild cognitive impairment.
The 2 groups in the trial
- Active TIS followed by Placebo TISTreatment being tested
Participants first receive single-session active TIS targeting the hippocampus for approx. 20 minutes. Following a washout period, they receive placebo (sham) TIS.
Treatment: Active Temporal Interference Stimulation (TIS) and Placebo / Sham TIS
- Placebo TIS followed by Active TISTreatment being tested
Participants first receive single-session placebo (sham) TIS for approx. 20 minutes. Following a washout period, they receive active TIS targeting the hippocampus.
Treatment: Active Temporal Interference Stimulation (TIS) and Placebo / Sham TIS
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Effects of Transcranial Temporal Interferential Electrical Stimulation on Cognitive Function, Dual-Task Performance and Neuroplasticity in Individuals With Mild Cognitive Impairment
- Record updated
- 5 November 2026