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Behavioral support to keep weight off after stopping weight loss medicines

Tests a behavioral program for keeping weight off after stopping GLP-1 medicines.

Key facts

Who runs it
University of Alabama at Birmingham
Where
Birmingham, United StatesSee the site
Trial code
Registry title
Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation
Status
Not yet recruiting
People taking part
64 people, planned
Started
1 Nov 2026
Expected to end
31 Jul 2029
Type of study
Interventional, 8 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Weight Loss Maintenance Program (Foundational)
  • Mom's Meals
  • YMCA Membership
  • SKY Meditation Program
Record updated
26 June 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults who lost at least 15% of their body weight with an anti-obesity medication and have stopped it or are about to stop it. It tests a 6-month program to help keep the weight off.

Age
18 years or older
Sex
All sexes can join
Disease stage
Lost 15% or more of starting body weight using anti-obesity medication, with 3 kg (7 lb) or less of weight regain in the past 3 months
Earlier treatment
Must have stopped anti-obesity medication within the past 4 weeks, or plan to stop before randomization

Main reasons for not taking part

  • Medical conditions that make physical activity, diet changes or mind-based practices unsafe
  • Active psychiatric conditions that would interfere with taking part, such as untreated major depression
  • Pregnancy, breastfeeding, or plans to become pregnant during the study
  • Currently in another structured weight loss or weight maintenance program
  • Still using anti-obesity medication after randomization

The registry criteria, word for word

Show all 18 criteriaShow less

Who can take part

  • Age 18 years or older
  • Loss of ≥15% of initial body weight using anti-obesity medication
  • Discontinued anti-obesity medication within the past 4 weeks or planning to discontinue prior to randomization
  • ≤3 kg weight regain within the past 3 months
  • Willing and able to participate in a 6-month behavioral intervention, including a 10-week foundational program
  • Willing to complete study assessments at baseline, 3 months, and 6 months, including required in-person visits
  • Medical clearance for participation in moderate physical activity, dietary modification, and mind-based practices
  • Access to reliable internet for participation in virtual sessions and remote data collection
  • English fluency sufficient to complete study procedures
  • Able to provide informed consent

Who cannot take part

  • Continued use of anti-obesity medication after randomization
  • Plans to initiate medications or treatments that may significantly affect body weight during the study period
  • Medical conditions that would preclude safe participation in physical activity, dietary changes, or mind-based practices (e.g., unstable cardiovascular disease, uncontrolled hypertension, severe orthopedic limitations, or seizure disorders not medically managed)
  • Active psychiatric conditions that would interfere with participation or safety (e.g., untreated major depression, active substance use disorder, or psychosis)
  • Any condition that, in the opinion of the investigators, would compromise participant safety or study integrity
  • Pregnancy, breastfeeding, or plans to become pregnant during the study period
  • Current participation in another structured weight loss or weight maintenance program
  • Inability to attend required study visits or participate in virtual sessions and remote data collection

Where in United States

  • University of Alabama at BirminghamBirmingham, United StatesContact: Holly Wyatt, MDNot yet recruiting

About the trial

What the trial wants to find out

This study is a single-site, pilot randomized factorial trial designed to evaluate the feasibility, acceptability, participant perceptions and preliminary effects of a multi-component behavioral intervention to support weight loss maintenance following discontinuation of GLP-1 and other anti-obesity medications. The intervention includes a standardized 10-week foundational weight loss maintenance program combined with candidate support components, including medically tailored meals, YMCA membership, and a structured mind-based program. Participants will be randomized using a 2 × 2 × 2 factorial design and followed for six months. Findings from this pilot study will inform optimization of a scalable intervention for future clinical trials.

The 8 groups in the trial

  • Group 1: WLM Program + Mom's Meals + YMCA + SKYExisting treatment, for comparison

    Eight participants will be assigned to the foundational WLM program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive three candidate support components: (1) medically tailored meals (Mom's Meals), (2) YMCA membership to support physical activity, and (3) the SKY Meditation program to support mind-based practices.

    Treatment: Weight Loss Maintenance Program (Foundational), Mom's Meals, YMCA Membership, and SKY Meditation Program

  • Group 2: WLM Program + Mom's Meals + YMCAExisting treatment, for comparison

    Eight Participants will be assigned to the foundational program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive two candidate support components: (1) medically tailored meals (Mom's Meals), (2) YMCA membership to support physical activity.

    Treatment: Weight Loss Maintenance Program (Foundational), Mom's Meals, and YMCA Membership

  • Group 3: WLM Program + Mom's Meals + SKYExisting treatment, for comparison

    Eight Participants will be assigned to the foundational program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive candidate support components: (1) medically tailored meals (Mom's Meals), and (3) the SKY Meditation program to support mind-based practices.

    Treatment: Weight Loss Maintenance Program (Foundational), Mom's Meals, and SKY Meditation Program

  • Group 4: WLM Program + Mom's MealsExisting treatment, for comparison

    Eight Participants will be assigned to the foundational program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive candidate support components: (1) medically tailored meals (Mom's Meals).

    Treatment: Weight Loss Maintenance Program (Foundational) and Mom's Meals

  • Group 5: WLM Program + YMCA + SKYExisting treatment, for comparison

    Eight Participants will be assigned to the foundational program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive candidate support components: (2) YMCA membership to support physical activity, and (3) the SKY Meditation program to support mind-based practices.

    Treatment: Weight Loss Maintenance Program (Foundational), YMCA Membership, and SKY Meditation Program

  • Group 6: WLM Program + YMCAExisting treatment, for comparison

    Eight Participants will be assigned to the foundational program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive support components: (2) YMCA membership to support physical activity.

    Treatment: Weight Loss Maintenance Program (Foundational) and YMCA Membership

  • Group 7: WLM Program + SKYExisting treatment, for comparison

    Eight Participants will be assigned to the foundational program, participants will be randomized using a full factorial 2 × 2 × 2 design to receive support components: (3) the SKY Meditation program to support mind-based practices.

    Treatment: Weight Loss Maintenance Program (Foundational) and SKY Meditation Program

  • Group 8: Foundational WLM Program OnlyExisting treatment, for comparison

    Eight participants will receive the 10-week foundational program. One group (n=8) will receive only the foundational program without any additional components.

    Treatment: Weight Loss Maintenance Program (Foundational)

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Pilot Trial of a Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation
Plain-language title
Behavioral support to keep weight off after stopping weight loss medicinesGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
26 June 2026