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Taking people in United StatesNo phase

Genicular Artery Embolization for Knee Osteoarthritis

Key facts

Who runs it
Northwestern University
Where
Chicago, United StatesSee the site
Trial code
Status
Recruiting
People taking part
15 people, planned
Started
10 Jul 2026
Expected to end
10 Apr 2031
Type of study
Interventional
Treatments tested
  • Embosphere Microspheres
Record updated
14 July 2026

Who can take part

Age
40 years to 80 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 19 criteriaShow less

Who can take part

  • Age 40-80 years
  • Mild-to-moderate knee OA as determined by radiographs demonstrating Kellgren- Lawrence grade 2-3
  • Self-reported pain of at least 5/10 VAS questionnaire
  • Failure of conservative therapy, such as pain medications, for at least 3 months
  • Patient must understand and sign the informed consent
  • Patient can comply with the proposed follow-up schedule
  • Patient can follow the post-operative management

Who cannot take part

  • Previous knee arthroplasty on the intended knee
  • History of rheumatoid arthritis
  • Existing knee joint infection
  • Allergy to iodinated contrast resulting in anaphylaxis
  • Renal insufficiency precluding angiography (GFR < 50 mL/min)
  • Irreversible coagulopathy
  • Kellgren-Lawrence grade 1 or 4
  • Severe atherosclerosis as manifest by claudication and/or diminished peripheral pulses
  • Life expectancy < 6 months
  • Infectious arthritis
  • Pregnant or interested in becoming pregnant three months from the date of the GAE procedure
  • Involved in litigation or worker's compensation claims

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 40 and 80 years old?

Where in United States

  • Northwestern UniversityChicago, United StatesContact: Robert Lewandowski, MDTaking people

About the trial

What the trial wants to find out

Patients will be asked to take part in this research study because they have mild-to-moderate knee osteoarthritis (OA) and were referred clinically for a procedure called Genicular Artery Embolization (GAE). Osteoarthritis is the most common form of arthritis. It occurs when the protective cartilage that cushions the ends of the bones wears down over time. The symptoms of OA include pain or aching, stiffness, decreased range of motion, and swelling. The purpose of this study is to evaluate the safety and effectiveness of GAE for the treatment of knee pain attributed to OA.

Read full original descriptionShow less

Research participants will be in this research study for about 3 years. The study includes a screening visit, GAE procedure, and six follow-up visits.

At the screening visit, a review of their medical history, demographics, and medications will be collected; physical examination will be completed; knee x-ray will be done; and two questionnaires on your knee pain will be administered. The GAE procedure will involve receiving sedation or medication to help them relax, lidocaine injected under the skin in the area of the body where catheters will be inserted into one of your arteries and then using x-ray, a catheter will be directed to the arteries supplying the lining of the knee. Then tiny microspheres will be injected into the artery to decrease the blood supply to this knee joint tissue.

The follow-up visits up to 12 months will include a focused physical examination of the treated knee, documentation of medications, and two questionnaires will be administered. The follow-up visits at year 2 and 3 will include documentation of medications and any new treatments for OA as well as completion of two questionnaires. Follow-up visits maybe conducted in clinic or remotely.

The group in the trial

  • GAE ProcedureTreatment being tested

    All participants will undergo a procedure called Genicular Artery Embolization (GAE) that will be done to try to reduce the pain in their knees.

    Treatment: Embosphere Microspheres

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Genicular Artery Embolization for Patients With Mild-To-Moderate Knee Osteoarthritis
Fit questions
Built from NCT07537153, who can take part
Record updated
14 July 2026