Lower-dose ultrasound-guided steroid injection versus higher-dose standard injection for knee osteoarthritis
Compares two triamcinolone knee injection approaches in people with knee osteoarthritis.
Key facts
- Who runs it
- Sosi Dzhugarian
- Where
- Ventura, United StatesSee the 4 sites
- Trial code
- Registry title
- Comparing Treatment of Knee Osteoarthritis With Triamcinolone Injections Using 40mg With Landmark Guidance and 20mg With Ultrasound Guidance
- Status
- Enrolling by invitation
- Phase
- Phase 4
- People taking part
- 140 people, planned
- Started
- 12 Dec 2025
- Expected to end
- 8 Dec 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Triamcinolone knee injection without ultrasound guidance
- Triamcinolone knee injection with ultrasound guidance
- Record updated
- 22 April 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 50 and older with primary osteoarthritis (wear-and-tear arthritis) in one or both knees. Participants get a steroid injection in the knee, at one of two doses.
- Age
- 50 years and older
- Sex
- Men and women
- Disease stage
- Primary knee osteoarthritis of any severity, shown on X-ray and/or MRI, with at least one symptom in at least one knee.
- Earlier treatment
- People must already have been seen at one of the 4 study clinics by one of the 3 study providers. No steroid, HA or PRP injection into the knee joint in the past 3 months.
Main reasons for not taking part
- Skin infection at or near the injection site
- Fracture of the same knee in the past 6 months, or an artificial knee joint in the painful knee
- Uncontrolled bleeding disorder
- Not able to report symptoms because of memory or thinking problems, or not able to walk at all, even with a walking aid
- Pregnant, or less than 1 year after menopause
The registry criteria, word for word
Show all 17 criteriaShow less
Who can take part
- Subjects who have already been evaluated within at least one of the 4 study clinics with any of the 3 providers who will be administering the treatment
- Males or females age 50 and older
- Already had completion of imaging of the affected knee(s) via radiography and/or MRI
- Imaging demonstrates osteoarthritis of any severity
- Diagnosis of primary osteoarthritis of one or both knees
- One or more symptoms associated with the osteoarthritis of at least one knee
- Patients able to provide informed consent in English and/or Spanish
Who cannot take part
- Intra-articular corticosteroid injection within past 3 months
- Skin infection at or near area of injection site
- Uncontrolled bleeding disorder
- Inability to report symptoms due to cognitive impairment
- Recent fracture of the same knee joint within past 6 months
- Intra-articular HA injection within the past 3 months
- Intra-articular PRP injection within the past 3 months
- Presence of prosthetic knee joint in symptomatic knee
- Complete inability to ambulate, even with assistive device
- Any person who is pregnant or less than 1 year post-menopause
Where in United States
- Community Memorial Health Center - North Brent Street, 168 North Brent Street, Suite 302, Orthopedic Surgery Clinic, Ventura, California 93003Ventura, United StatesEnrolling by invitation
- Community Memorial Health Center - North Brent Street, 168 North Brent Street, Suite 302, Sports Medicine Clinic, Ventura, California 93003Ventura, United StatesEnrolling by invitation
- Community Memorial Health Center - Pirie Road, 117 Pirie Road, Orthopedic Surgery Clinic, Ojai, California 93023Ventura, United StatesEnrolling by invitation
- Community Memorial Health Center, 1320 Maricopa Highway, Ojai, California 93023Ventura, United StatesEnrolling by invitation
About the trial
What the trial wants to find out
The purpose of this study is to determine whether a lower dose of corticosteroid injection with ultrasound-guidance for the treatment of knee osteoarthritis can be as effective as a higher dose that is landmark-guided. With landmark-guided dosing, it may be reasonable to use a higher amount of corticosteroid in order to ensure a sufficient amount of the medication is administered, however these injections carry the risk of side effects. Alternatively, with the use of ultrasound, it may be reasonable to use less corticosteroid, possibly decreasing the risk of side effects and increasing patient satisfaction.
The 2 groups in the trial
- 40mg landmark-guided triamcinolone knee joint injectionExisting treatment, for comparison
Treatment: Triamcinolone knee injection without ultrasound guidance
- 20mg ultrasound-guided triamcinolone knee injectionTreatment being tested
Treatment: Triamcinolone knee injection with ultrasound guidance
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Non-Inferiority Study Comparing Treatment of Primary Knee Osteoarthritis With Intra-Articular Triamcinolone Injections Using 40mg With Landmark Guidance and 20mg With Ultrasound Guidance: The PRECISION-Knee Trial (PRospective Evaluation of the Clinical Impact of Steroid Injection Options iN Knee Osteoarthritis)
- Plain-language title
- Lower-dose ultrasound-guided steroid injection versus higher-dose standard injection for knee osteoarthritisGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Record updated
- 22 April 2026