Music therapy for pain and well-being in young people with sickle cell disease
Tests music therapy for chronic pain in young people with sickle cell disease.
Plain-language title generated from the registry record
Registry title: Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing
Key facts
- Where
- Atlanta, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 8 and 18 years old?
Source: NCT07562451, who can take part
Where in United States
- Children's Healthcare of AtlantaAtlanta, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Emory University
- Trial code
- NCT07562451
- Record updated
- 10 September 2026
- Original description
The goal of this clinical trial is to evaluate whether a 4-week music therapy (MT) intervention can reduce chronic pain and improve psychosocial outcomes in youth with sickle cell disease (SCD).Read full original descriptionShow less
Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing
The goal of this clinical trial is to evaluate whether a 4-week music therapy (MT) intervention can reduce chronic pain and improve psychosocial outcomes in youth with sickle cell disease (SCD).
The main questions it aims to answer are:
* Does MT reduce pain intensity, frequency of pain episodes, and improve health-related quality of life (HRQoL)? * Does MT alter immune cell composition and gene expression in inflammatory pathways, as measured by single-cell RNA sequencing (scRNA-seq)?
Researchers will compare participants randomized to music therapy versus a control condition to see if MT produces superior improvements in pain and psychosocial outcomes, and distinct molecular changes.
Inclusion: Diagnosed with SCD; English fluency (for survey completion); Have access to a personal electronic device (e.g., phone, tablet) with access to the internet; Meet the criteria for chronic pain defined by the International Association for the Study of Pain (IASP). IASP defines chronic pain as pain that is both:; Persistent or recurrent for ≥ 3 months; is associated with significant emotional distress or functional disability.30.
Exclusion: Major hearing deficiency or medical condition in which listening to music may be contraindicated (e.g., reflex epilepsy).