Taking peoplePhase 3
CagriSema versus semaglutide for weight loss in obesity, with or without type 2 diabetes
Compares CagriSema with semaglutide for weight loss in adults with obesity.
Plain-language title generated from the registry record
Registry title: A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
Key facts
- Where
- Amarillo, Aurora, Austin, Beaver, Belzoni, Birmingham, Buckley, Chesterfield, Chicago, Clearwater, Conyers, Cumberland, Dallas, Escondido, Euless, Fargo, Fleming Island, Gaffney, Gainesville, Gilbert, Gillespie, Green Bay, Greensboro, Greenville, Gurnee, Hatboro, Houston, Jackson, Jacksonville, Katy, Kerrville, Kingsport, La Mesa, Lampasas, Laredo, Lexington, Lincoln, Little Rock, Loma Linda, Longview, Los Alamitos, Maumee, McAllen, Memphis, Meridian, Miami, Minneapolis, Miramar, Morehead City, Morristown, Nashville, Newport News, Newton, Norman, Northridge, Ocoee, Oviedo, Palm Springs, Pelham, Pembroke Pines, Philadelphia, Phoenix, Richfield, Richmond, Rockville, Roswell, Salt Lake City, San Antonio, San Diego, Sandy City, Shavano Park, Skokie, South Jordan, Spartanburg, St Louis, Statesville, Sugar Land, Topeka, Van Nuys, Walnut Creek, West Des Moines, West Seneca, Wilmington, and Woodstock, United StatesSee the 98 sites
- Phase
- Phase 3
Where in United States
- Amarillo Med Spec LLPAmarillo, United StatesNo longer taking part
- University of Colorado HospitalAurora, United StatesNo longer taking part
- Texas Diab & Endo, P.A.Austin, United StatesNo longer taking part
- Velocity Clinical Research AustinAustin, United StatesNo longer taking part
- Heritage Valley Medical GroupBeaver, United StatesNot yet recruiting
- Belzoni Clinical ResearchBelzoni, United StatesNo longer taking part
- Uni of Alabama at BirminghamBirmingham, United StatesNo longer taking part
- Northern Pines Hlth Ctr, PCBuckley, United StatesNo longer taking part
- Clinical Research ProfessionalsChesterfield, United StatesNo longer taking part
- Cedar Crosse Research CenterChicago, United StatesNo longer taking part
- TBMR & AlcanzaClearwater, United StatesNo longer taking part
- Hope Clin Res & WellnessConyers, United StatesNo longer taking part
- Clinical Res CollaborativeCumberland, United StatesNo longer taking part
- North Texas Endocrine CenterDallas, United StatesNo longer taking part
- Velocity Clin Res, DallasDallas, United StatesNo longer taking part
- Headlands Research California, LLCEscondido, United StatesNo longer taking part
- Neighborhood HealthcareEscondido, United StatesNo longer taking part
- Cedar Health ResearchEuless, United StatesNo longer taking part
- Plains Clinical Research Center, LLCFargo, United StatesNot yet recruiting
- Lillestol Research, LLCFargo, United StatesNo longer taking part
- Northeast Research InstituteFleming Island, United StatesNo longer taking part
- Velocity Clinical Research, GaffneyGaffney, United StatesNo longer taking part
- Center for Adv Res & EducationGainesville, United StatesNo longer taking part
- Elligo Health Research IncGilbert, United StatesNo longer taking part
- Macoupin Fam Practice Ctr, LLPGillespie, United StatesNo longer taking part
- Prevea HealthGreen Bay, United StatesNot yet recruiting
- PharmQuest Life Sciences LLCGreensboro, United StatesNo longer taking part
- Physician's East EndocrinologyGreenville, United StatesNo longer taking part
- Clinical Investigation Spec GurneeGurnee, United StatesNo longer taking part
- Hatboro Med AssociatesHatboro, United StatesNo longer taking part
- JCCT- Juno NW HoustonHouston, United StatesNo longer taking part
- The Endocrine CenterHouston, United StatesNo longer taking part
- Jackson ClinicJackson, United StatesNo longer taking part
- Northeast Research InstituteJacksonville, United StatesNo longer taking part
- Westside Center for Clinical ResearchJacksonville, United StatesNo longer taking part
- Medical Colleagues-Texas LLPKaty, United StatesNo longer taking part
- Sante Clinical ResearchKerrville, United StatesNo longer taking part
- Holston Medical Group.Kingsport, United StatesNo longer taking part
- Diabetes & Endocrine Specialists - La MesaLa Mesa, United StatesNo longer taking part
- Radiance Clinical ResearchLampasas, United StatesNo longer taking part
- Aeres Clinical ResearchLaredo, United StatesNo longer taking part
- The Research Group of Lexington LLCLexington, United StatesNo longer taking part
- Clinical Trials Research_SacramentoLincoln, United StatesNo longer taking part
- Arkansas Clinical ResearchLittle Rock, United StatesNo longer taking part
- Woodland Int. Research GroupLittle Rock, United StatesNo longer taking part
- Loma Linda University Faculty Medical ClinicsLoma Linda, United StatesNo longer taking part
- DCOL Ctr for Clin ResLongview, United StatesNo longer taking part
- Pacific Clinical StudiesLos Alamitos, United StatesNo longer taking part
- Advanced Medical ResearchMaumee, United StatesNo longer taking part
- RGV Endocrine CenterMcAllen, United StatesNo longer taking part
- CNS HealthcareMemphis, United StatesNo longer taking part
- Solaris Clinical ResearchMeridian, United StatesNo longer taking part
- Bioclinical Research AllianceMiami, United StatesNo longer taking part
- New Horizon Research CenterMiami, United StatesNo longer taking part
- International Diabetes CenterMinneapolis, United StatesNot yet recruiting
- South Broward Research LLCMiramar, United StatesNo longer taking part
- Carteret Medical GroupMorehead City, United StatesNo longer taking part
- Centricity Rsrch MHCity MultiMorehead City, United StatesNo longer taking part
- HealthStar Physicians, PCMorristown, United StatesNo longer taking part
- Clinical Research AssociatesNashville, United StatesNo longer taking part
- Health Res of Hampton RoadsNewport News, United StatesNo longer taking part
- Tidewater Physicians Multispecialty GroupNewport News, United StatesNo longer taking part
- Alliance for Multispecialty ResearchNewton, United StatesNo longer taking part
- Alliance for Multispecialty ResearchNorman, United StatesNo longer taking part
- Lynn Institute of NormanNorman, United StatesNo longer taking part
- Valley Clinical TrialsNorthridge, United StatesNo longer taking part
- West Orange EndocrinologyOcoee, United StatesNo longer taking part
- Oviedo Medical Research, LLCOviedo, United StatesNo longer taking part
- Desert Oasis HealthcarePalm Springs, United StatesNo longer taking part
- Cahaba ResearchPelham, United StatesNo longer taking part
- Clinical Trial Services CorpPembroke Pines, United StatesNo longer taking part
- Northeast Endocrine Metabolic AssociatesPhiladelphia, United StatesNo longer taking part
- Velocity Clinical Research, PhoenixPhoenix, United StatesNo longer taking part
- AES Minneapolis DRSRichfield, United StatesNo longer taking part
- National Clin Res Inc.Richmond, United StatesNo longer taking part
- Endo and Metabolic ConsultantsRockville, United StatesNot yet recruiting
- Endocrine Research Solutions, IncRoswell, United StatesNo longer taking part
- J.Lewis Research IncSalt Lake City, United StatesNo longer taking part
- AES San AntonioSan Antonio, United StatesNo longer taking part
- Northeast Clinical Research of San AntonioSan Antonio, United StatesNo longer taking part
- Quality Research IncSan Antonio, United StatesNo longer taking part
- Linda Vista Health Care CtrSan Diego, United StatesNo longer taking part
- Diabetes & Endo Tx SpecialistsSandy City, United StatesNo longer taking part
- Consano Clinical Research, LLCShavano Park, United StatesNo longer taking part
- Endeavor HealthSkokie, United StatesNo longer taking part
- Evanston Premier Hlthcr ResSkokie, United StatesNo longer taking part
- J.Lewis Research IncSouth Jordan, United StatesNo longer taking part
- Spartanburg Medical ResearchSpartanburg, United StatesNo longer taking part
- Amicis Centers of Clinical ResearchSt Louis, United StatesNo longer taking part
- Piedmont Healthcare/ResearchStatesville, United StatesNo longer taking part
- Mt Olympus Medical Research, LLCSugar Land, United StatesNo longer taking part
- Cotton O'Neil Diab & Endo CtrTopeka, United StatesNo longer taking part
- Velocity Clin Res - Van NuysVan Nuys, United StatesNo longer taking part
- Flourish Research - CAWalnut Creek, United StatesNo longer taking part
- Iowa Diabetes ResearchWest Des Moines, United StatesNo longer taking part
- Southgate Medical Group, LLPWest Seneca, United StatesNo longer taking part
- Accellacare - WilmingtonWilmington, United StatesNo longer taking part
- North Georgia Clinical ResearchWoodstock, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Novo Nordisk A/S
- Trial code
- NCT07564414EU 2025-522488-14-00
- Record updated
- 30 September 2026
- Original description
This clinical study is testing how the study medicine CagriSema helps people living with obesity, with or without type 2 diabetes (T2D), lose weight. The purpose of the study is to find out how safe and effective CagriSema is for body weight loss in these participants. Participants will receive either CagriSema or semaglutide, and which treatment participants receive is decided by chance. CagriSema is a new study medicine being tested, while semaglutide is a medicine that doctors can already prescribe. The study will last for about 83 weeksRead full original descriptionShow less
A Clinical Study to Compare Efficacy and Safety of Two Different Doses of CagriSema and Semaglutide in Participants With Obesity With or Without Type 2 Diabetes
This clinical study is testing how the study medicine CagriSema helps people living with obesity, with or without type 2 diabetes (T2D), lose weight. The purpose of the study is to find out how safe and effective CagriSema is for body weight loss in these participants. Participants will receive either CagriSema or semaglutide, and which treatment participants receive is decided by chance. CagriSema is a new study medicine being tested, while semaglutide is a medicine that doctors can already prescribe. The study will last for about 83 weeks
Inclusion: Male or female (sex assigned at birth, inclusive of all gender identities); Age 18 years or above at the time of signing the informed consent; BMI≥ 35.0 kg/m\^2; Participants without T2D: No history of T2D and HbA1c < 6.5% (48 millimoles per mole (mmol/mol)) Participants with T2D: A history of T2D and HbA1c < 10% (< 86 mmol/mol). If a participant without a history of diabetes during the screening period receives an HbA1c result of 6.5% (48 mmol/mol) or higher, the investigator or the participant's healthcare provider must confirm the diagnosis of type 2 diabetes before the participant is randomised.
Exclusion: A self-reported change in body weight > 5% within 90 days before screening, irrespective of medical records; Use of any glucagon-like-peptide-1 receptor agonist (GLP-1 RA), including medication with GLP-1 RA activity, or amylin analogues, including medication with amylin activity, within 6 months before screening.