Taking people in United StatesPhase 3
Testing NNC0487-0111 Against Placebo in Adults With Heart Failure and Excess Weight
Tests the weekly injection NNC0487-0111 against placebo in adults with heart failure and obesity.
Plain-language title generated from the registry record
Registry title: A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
Key facts
- Where
- Acworth, Albany, Alexander City, Alhambra, Amarillo, Apex, Atlanta, Aurora, Austin, Baltimore, Beverly Hills, Biddeford, Birmingham, Bloomfield Hills, Bossier City, Bowie, Brooklyn, Camp Hill, Canton, Chambersburg, Charleston, Charlottesville, Chicago, Chula Vista, Cincinnati, Clearwater, Cleveland, Concord, Conroe, Conyers, Coral Gables, Corpus Christi, Covina, Crystal River, Dallas, Davenport, Dayton, Daytona Beach, Denison, Denver, Diamondhead, Doylestown, Duncanville, Durham, El Paso, Elmer, Eunice, Fairhope, Florida City, Forney, Fort Mill, Fort Worth, Fremont, Ft. Washington, Gainesville, Gilbert, Glendale, Golden, Granada Hills, Grand Rapids, Greeneville, Greenville, Hackettstown, Haddon Heights, Hammond, Hazel Crest, Honolulu, Houma, Houston, Huntington Beach, Huntington Park, Indianapolis, Iowa City, Irvine, Jackson, Jacksonville, Jersey City, Johns Creek, Kansas City, La Jolla, Lancaster, Lansing, Las Vegas, Lenoir, Lexington, Lincoln, Little Rock, Long Beach, Los Alamitos, Los Angeles, Louisville, Maitland, Manassas, Marion, Marshfield, Maumee, McAllen, McKinney, Meridian, Miami, Miami Beach, Miami Lakes, Milwaukee, Mobile, Morgantown, Murray, New Port Richey, New York, Newport News, Norfolk, Northridge, Ocala, Opelousas, Orland Park, Orlando, Ormond Beach, Owensboro, Palm Springs, Paramus, Peachtree, Pembroke Pines, Pensacola, Peoria, Philadelphia, Phoenix, Plano, Pomona, Portland, Raleigh, Rapid City, Richmond, Rochester, Rockville, Rosedale, Round Rock, Safety Harbor, San Antonio, San Diego, San Francisco, San Marcos, Santa Maria, Santa Rosa, Sarasota, Seattle, Sewell, Sherman, Shreveport, Somerset, Southfield, St Louis, Statesville, Stockton, Tacoma, Tampa, Tarzana, Temple, Thomasville, Thousand Oaks, Tucker, Valhalla, Van Nuys, Vandalia, Vienna, Virginia Gardens, Vista, Washington D.C., Wausau, West Hills, Wichita, Wilmington, Winchester, Winter Park, and Ypsilanti, United StatesSee the 206 sites
- Phase
- Phase 3
Where in United States
- American Clinical Trials, LLC.Acworth, United StatesTaking people
- Capital Cardiology Associates_AlbanyAlbany, United StatesTaking people
- Advanced Cardiovascular, LLCAlexander City, United StatesTaking people
- InvivoCure -2Alhambra, United StatesTaking people
- PharmaTex Research, LLCAmarillo, United StatesTaking people
- Peak Clinical TrialsApex, United StatesTaking people
- Atlanta Center for Clinical Research_AtlantaAtlanta, United StatesTaking people
- Univ of Colorado at DenverAurora, United StatesTaking people
- VA Eastern Colorado Health Care SystemAurora, United StatesNot yet recruiting
- Austin HeartAustin, United StatesNot yet recruiting
- Ascension Saint Agnes Heart CaBaltimore, United StatesNot yet recruiting
- Mercy Medical Center, GI ResearchBaltimore, United StatesNot yet recruiting
- Cardio Research of S. CalBeverly Hills, United StatesTaking people
- Westside Medical Associates Los AngelesBeverly Hills, United StatesTaking people
- MaineHealth Cardiology - BiddefordBiddeford, United StatesNot yet recruiting
- Univ of Alabama BirminghamBirmingham, United StatesNot yet recruiting
- Cardio and Vascular Assoc-CAVABloomfield Hills, United StatesTaking people
- Grace Research LLCBossier City, United StatesTaking people
- Flourish Research - BowieBowie, United StatesTaking people
- Clindove ResearchBrooklyn, United StatesTaking people
- Penn State Hlth Holy Spirit Med CtrCamp Hill, United StatesNot yet recruiting
- Aultman HospitalCanton, United StatesNot yet recruiting
- Chambersburg HospitalChambersburg, United StatesNot yet recruiting
- Med. Uni. of SC Ashley River TCharleston, United StatesTaking people
- University Of Virginia HospitalCharlottesville, United StatesNot yet recruiting
- Chicago Clinical Research Institute INCChicago, United StatesTaking people
- Eagle Clinical ResearchChicago, United StatesTaking people
- Univer Of Illinois at ChicagoChicago, United StatesNot yet recruiting
- Scripps HospitalChula Vista, United StatesTaking people
- Lindner Center,Christ HospitalCincinnati, United StatesNot yet recruiting
- BayCare Health SystemClearwater, United StatesTaking people
- Louis Stokes Clvlnd VA Med CtrCleveland, United StatesNot yet recruiting
- Hawthorne Health NCConcord, United StatesTaking people
- John Muir Physicians NetworkConcord, United StatesTaking people
- Javara Inc. / Privia Medical Group Gulf Coast PLLCConroe, United StatesTaking people
- East Atlanta CardiologyConyers, United StatesTaking people
- Hope Clin Res & WellnessConyers, United StatesTaking people
- Broward Research Ctr.Coral Gables, United StatesTaking people
- South Texas Clinical ResearchCorpus Christi, United StatesTaking people
- Valley Clinical TrialsCovina, United StatesTaking people
- Nature Coast Clinical ResearchCrystal River, United StatesTaking people
- Renal Disease Research InstituteDallas, United StatesTaking people
- Southwest Family Medicine_DallasDallas, United StatesTaking people
- Texas Health Heart and Vascular SpecialistsDallas, United StatesNot yet recruiting
- UTD SW Medical Center-DallasDallas, United StatesTaking people
- Midwest Cardiovascu Rsrch FoundationDavenport, United StatesNot yet recruiting
- Providence Health Partners CtrDayton, United StatesTaking people
- Arrow Clinical TrialsDaytona Beach, United StatesTaking people
- Texama Medical CenterDenison, United StatesTaking people
- Intermountain Heart & VascularDenver, United StatesNot yet recruiting
- Hawthorne HealthDiamondhead, United StatesNot yet recruiting
- Doylestown Heath cardiologyDoylestown, United StatesNot yet recruiting
- Dallas Heart and VascularDuncanville, United StatesTaking people
- Duke UniversityDurham, United StatesNot yet recruiting
- David Turbay MD PLLCEl Paso, United StatesTaking people
- Proactive El Paso LLCEl Paso, United StatesTaking people
- Heart House - VinelandElmer, United StatesNot yet recruiting
- Horizon Research Group of Opelousas LLCEunice, United StatesTaking people
- Eastern Shore Rsrch Inst, LLCFairhope, United StatesTaking people
- Inpatient Research Clinic LLCFlorida City, United StatesTaking people
- Care United Research, LLCForney, United StatesTaking people
- Piedmont Research Partners LLCFort Mill, United StatesTaking people
- Baylor Scott & White HealthFort Worth, United StatesNot yet recruiting
- Mission Cardiovascular Research InstituteFremont, United StatesTaking people
- Anderson Medical GroupFt. Washington, United StatesTaking people
- Northeast Georgia Medical CtrGainesville, United StatesTaking people
- Mercy Gilbert Medical CenterGilbert, United StatesTaking people
- Sun City Clinical ResearchGlendale, United StatesTaking people
- Colorado Heart and Vascular PCGolden, United StatesTaking people
- Amicis Research CenterGranada Hills, United StatesTaking people
- Corewell HealthGrand Rapids, United StatesNot yet recruiting
- Balad Hlth Sys-Welmont CardCVAGreeneville, United StatesTaking people
- Physicians East EndocrinologyGreenville, United StatesNot yet recruiting
- Advanced Cardiology LLC - HackettstownHackettstown, United StatesNot yet recruiting
- The Heart House Haddon HeightsHaddon Heights, United StatesNot yet recruiting
- Asha Clinical Rsch-Munster, LLCHammond, United StatesTaking people
- Chicago Medical Research LLCHazel Crest, United StatesTaking people
- The Queen's Medical CenterHonolulu, United StatesNot yet recruiting
- Cardiovascular Institute of the SouthHouma, United StatesTaking people
- Card Specialists of WillowbrookHouston, United StatesTaking people
- East Texas Cardiology PAHouston, United StatesTaking people
- Main Heart ClinicHouston, United StatesTaking people
- Victorium Clinical ResearchHouston, United StatesTaking people
- California Heart SpecialistHuntington Beach, United StatesTaking people
- Valiance Clinical ResearchHuntington Park, United StatesTaking people
- Indiana University Health Methodist HospitalIndianapolis, United StatesTaking people
- University of IowaIowa City, United StatesNot yet recruiting
- Joe C.Wen & Fam CTR for Adv CareIrvine, United StatesNot yet recruiting
- The Jackson Clinic, PAJackson, United StatesTaking people
- Univ of Mississippi Med CenterJackson, United StatesNot yet recruiting
- Jacksonville Ctr for Clin ResJacksonville, United StatesTaking people
- Jersey City Medical CenterJersey City, United StatesNot yet recruiting
- NSC Research, IncJohns Creek, United StatesTaking people
- Clinical Research Consultants, JCCT CoKansas City, United StatesTaking people
- Scripps Memorial Hospital La JollaLa Jolla, United StatesNot yet recruiting
- UCSD NAFLD Research CenterLa Jolla, United StatesNot yet recruiting
- Penn Med. Lancaster Gen HospitalLancaster, United StatesTaking people
- University Of MichiganLansing, United StatesTaking people
- Palm Research Center Inc-VegasLas Vegas, United StatesTaking people
- UMC of Southern NevadaLas Vegas, United StatesNot yet recruiting
- IMA ResearchLenoir, United StatesTaking people
- The Research Group of Lexington LLCLexington, United StatesTaking people
- Bryan HeartLincoln, United StatesNot yet recruiting
- Velocity Clinical Research - LincolnLincoln, United StatesTaking people
- Arkansas Health GroupLittle Rock, United StatesNot yet recruiting
- Cardio Innovation & Resch CtrLong Beach, United StatesTaking people
- Pacific Clinical StudiesLos Alamitos, United StatesTaking people
- VAGrtrLosAngelesHlthcareSystemLos Angeles, United StatesNot yet recruiting
- UofL Health Care OutpatientLouisville, United StatesNot yet recruiting
- K2 Medical ResearchMaitland, United StatesTaking people
- Carient Heart and VascularManassas, United StatesNot yet recruiting
- K&R Research LLCMarion, United StatesTaking people
- Marshfield ClinicMarshfield, United StatesNot yet recruiting
- Advanced Medical ResearchMaumee, United StatesTaking people
- Biopharma Informatic, LLCMcAllen, United StatesTaking people
- North Texas Research AssociatesMcKinney, United StatesTaking people
- High Desert Heart and Vascular PLLCMeridian, United StatesNot yet recruiting
- St. Luke's Idaho Cardiology AssociatesMeridian, United StatesNot yet recruiting
- Future Life Clinical TrialsMiami, United StatesTaking people
- Infinite Clinical ResearchMiami, United StatesTaking people
- Total Research Group LLCMiami, United StatesTaking people
- Broward Research Ctr.Miami Beach, United StatesTaking people
- Inpatient Research Clinic LLCMiami Lakes, United StatesTaking people
- Aurora St. Luke's Medi CtrMilwaukee, United StatesNot yet recruiting
- Mobile Heart USA Health Cardiology ClinicMobile, United StatesNot yet recruiting
- WVU MedicineMorgantown, United StatesNot yet recruiting
- Intermountain Medical CenterMurray, United StatesNot yet recruiting
- Suncoast Clinical Research, Inc.New Port Richey, United StatesTaking people
- Columbia University Medical Center_New YorkNew York, United StatesNot yet recruiting
- Mount Sinai Hosp at NYCNew York, United StatesNot yet recruiting
- NYU Langone Med Assoc ChelseaNew York, United StatesNot yet recruiting
- NYU Langone Orthopedic CenterNew York, United StatesNot yet recruiting
- TPMG Clinical ResearchNewport News, United StatesTaking people
- Sentara Health Research CenterNorfolk, United StatesTaking people
- Amicis Research CenterNorthridge, United StatesTaking people
- JPJ ResearchNorthridge, United StatesTaking people
- Valley Clinical TrialsNorthridge, United StatesTaking people
- Ocala Cardiovascular ResearchOcala, United StatesTaking people
- Cardiovascular Institute of the SouthOpelousas, United StatesTaking people
- Chicago Clinical Research Institute INCOrland Park, United StatesTaking people
- Cardiovascular Institute of OrlandoOrlando, United StatesTaking people
- Ormond Beach Clinical ResearchOrmond Beach, United StatesTaking people
- Research Integrity Global, LLCOwensboro, United StatesTaking people
- Desert Oasis HealthcarePalm Springs, United StatesTaking people
- The Valley Hospital ParamusParamus, United StatesNot yet recruiting
- Peachtree CardiologyPeachtree, United StatesTaking people
- DBC Research - Pembroke PinesPembroke Pines, United StatesTaking people
- Sec Clinical ResearchPensacola, United StatesTaking people
- Methodist Medical Center of IllinoisPeoria, United StatesTaking people
- Thomas Jefferson UniversityPhiladelphia, United StatesNot yet recruiting
- Arizona Research CenterPhoenix, United StatesNot yet recruiting
- Honor HealthPhoenix, United StatesNot yet recruiting
- Baylor Scott & White Res InstPlano, United StatesNot yet recruiting
- AtlantiCare Regional Medical CenterPomona, United StatesNot yet recruiting
- Empire Clin. ResearchPomona, United StatesNot yet recruiting
- Oregon Health Science UniversityPortland, United StatesNot yet recruiting
- WakeMed_CardiologyRaleigh, United StatesNot yet recruiting
- Monument Health Clinical RsrchRapid City, United StatesNot yet recruiting
- Virginia Commonwealth UniversityRichmond, United StatesNot yet recruiting
- University of RochesterRochester, United StatesNot yet recruiting
- Adventist HealthCare Shady Grove Medical CenterRockville, United StatesTaking people
- Laurelton Heart Specialist, PCRosedale, United StatesNot yet recruiting
- Baylor Scott & White HealthRound Rock, United StatesNot yet recruiting
- Clearwater Cardiovascular ConsultantsSafety Harbor, United StatesTaking people
- University HospitalSan Antonio, United StatesTaking people
- G&J ResearchSan Diego, United StatesTaking people
- San Diego Veterans AffairsSan Diego, United StatesTaking people
- Kaiser Permanente Northern CaliforniaSan Francisco, United StatesNot yet recruiting
- San Francisco V.A. Medical CenterSan Francisco, United StatesNot yet recruiting
- Austin HeartSan Marcos, United StatesNot yet recruiting
- FOMAT Medical ResearchSanta Maria, United StatesTaking people
- NorthBay Clinical ResearchSanta Rosa, United StatesTaking people
- Intercoastal Medical GroupSarasota, United StatesNot yet recruiting
- Swedish Medical Center_SeattleSeattle, United StatesNot yet recruiting
- Heart House - SewellSewell, United StatesTaking people
- Medrasa Clinical ResearchSherman, United StatesTaking people
- Sherman Clinical ResearchSherman, United StatesTaking people
- Grace Research, LLC_ShreveportShreveport, United StatesNot yet recruiting
- Cardio Metabolic InstituteSomerset, United StatesTaking people
- Henry Ford Health SystemSouthfield, United StatesTaking people
- Amicis Centers of Clinical ResearchSt Louis, United StatesTaking people
- Washington UniversitySt Louis, United StatesTaking people
- PHC AccelacareStatesville, United StatesTaking people
- St. Joseph's Medical CenterStockton, United StatesNot yet recruiting
- CHI Franciscan Research CenterTacoma, United StatesNot yet recruiting
- St Joseph's Hospital FoundationTampa, United StatesTaking people
- Tampa Cardiovascular Interventions and ResearchTampa, United StatesTaking people
- Valiance Clinical ResearchTarzana, United StatesTaking people
- Baylor Scott & White HealthTemple, United StatesNot yet recruiting
- Cardiovascular Consultants of South GeorgiaThomasville, United StatesTaking people
- Care Access ResearchThousand Oaks, United StatesTaking people
- Atlanta Heart Specialists LLCTucker, United StatesTaking people
- Westchester Medical CenterValhalla, United StatesNot yet recruiting
- InvivoCureVan Nuys, United StatesTaking people
- STAT Research OhioVandalia, United StatesTaking people
- Conquest ResearchVienna, United StatesTaking people
- Hope Research NetworkVirginia Gardens, United StatesTaking people
- Blue Coast Research CenterVista, United StatesTaking people
- The GW Medical Faculty AssociatesWashington D.C., United StatesNot yet recruiting
- Cardio Research & Education FoundationWausau, United StatesTaking people
- Interventional Cardiology Medical GroupWest Hills, United StatesTaking people
- West Houston Area Clinical Trial ConsultantsWichita, United StatesNot yet recruiting
- Accellacare - WilmingtonWilmington, United StatesNot yet recruiting
- Selma Medical AssociatesWinchester, United StatesTaking people
- Guardian Research Org LLCWinter Park, United StatesTaking people
- Trinity Health Michigan HeartYpsilanti, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Novo Nordisk A/S
- Trial code
- NCT07567001EU 2025-523717-29-00
- Record updated
- 18 August 2026
- Original description
This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have HFpEF or HFmrEF and excess body weight. Participants will get NNC0487-0111 or placebo by injection once a week. Which treatment participants get is decided by chance. NNC0487-0111 is a new medicine that doctors cannot prescribe yet, but it has been tested in people before.Read full original descriptionShow less
Efficacy and Safety of NNC0487-0111 Compared to Placebo on Morbidity and Mortality in People With Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have HFpEF or HFmrEF and excess body weight. Participants will get NNC0487-0111 or placebo by injection once a week. Which treatment participants get is decided by chance. NNC0487-0111 is a new medicine that doctors cannot prescribe yet, but it has been tested in people before.
Inclusion: Body Mass Index (BMI) greater than or equal to (>=) 30 kilograms per square metre (kg/m\^2) at screening; Diagnosis of HF with New York Heart Association (NYHA) class II-IV and in stable condition at screening, at the discretion of the investigator; For participants with Type 2 Diabetes (T2D) at screening:; Diagnosed with T2D >= 30 days before screening.
Exclusion: MI, stroke, unstable angina pectoris or worsening HF leading to either hospitalization or intravenous loop diuretics within 30 days prior to the day of screening and until randomization; requiring home oxygen; or - ongoing oral corticosteroid therapy; or - hospital for COPD Exacerbation within 12 months prior to screening; Participant with diabetic retinopathy or maculopathy who received treatment with retinal photocoagulation, vitrectomy or anti-Vascular Endothelial Growth Factor (anti-VEGF) within 180 days before screening or who, at the time of screening, are expected to require treatment within 180 days after screening. Diabetic retinopathy or maculopathy must be verified by an eye examination performed within 90 days before screening or in the period between screening and randomization. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination; HF due to infiltrative cardiomyopathy (e.g., sarcoid, amyloid), arrhythmogenic right ventricular cardiomyopathy, Takutsubo cardiomyopathy, Chagas cardiomyopathy, genetic hypertrophic cardiomyopathy or obstructive cardiomyopathy, active myocarditis, constrictive pericarditis, cardiac tamponade, or uncorrected primary valve disease of moderate or severe degree; Severe pulmonary disease including primary pulmonary hypertension, chronic pulmonary embolism, or severe chronic obstructive pulmonary disease (COPD) defined as:; Any other condition judged by the investigator to be the cause of HF symptoms (e.g., anaemia, hypothyroidism); Glycaemia-related:; History of type 1 diabetes; Glycated haemoglobin (HbA1c) greater than (>) 10 percent (%) (86 [millimoles per mole] mmol/mol) as measured by local or central laboratory at screening.