Brain imaging in young people at risk of suicide, before and after CAMS therapy
Studies brain activity in young people with suicidal thoughts, before and after CAMS therapy.
Plain-language title generated from the registry record
Registry title: Neural Correlates of Suicidal Behavior in Youth
Key facts
- Where
- Cleveland, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 14 and 24 years old?
Source: NCT07568054, who can take part
Where in United States
- The Cleveland ClinicCleveland, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The Cleveland Clinic
- Trial code
- NCT07568054
- Record updated
- 3 September 2026
- Original description
This study, titled "Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study," aims to better understand the brain mechanisms underlying suicidal thoughts and behaviors in adolescents and young adults (ages 14-24). Suicide is a leading cause of death in this population, and current clinical approaches often fail to accurately predict or prevent suicidal behavior. This study seeks to identify objective neurobiological markers associated with suicide risk and treatment response.Read full original descriptionShow less
Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study
This study, titled "Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study," aims to better understand the brain mechanisms underlying suicidal thoughts and behaviors in adolescents and young adults (ages 14-24). Suicide is a leading cause of death in this population, and current clinical approaches often fail to accurately predict or prevent suicidal behavior. This study seeks to identify objective neurobiological markers associated with suicide risk and treatment response.
Participants will be divided into three groups: (1) high-risk individuals recently hospitalized following a suicide attempt, (2) medium-risk individuals with chronic suicidal ideation but no attempts, and (3) low-risk healthy controls. All participants will undergo advanced neuroimaging, including magnetoencephalography (MEG) and magnetic resonance imaging (MRI), along with comprehensive psychiatric assessments.
The study focuses on brain regions and networks implicated in suicidality, including the anterior cingulate cortex and salience network, as well as neurochemical markers such as glutamate. It also examines electrophysiological activity and functional connectivity patterns associated with suicidal thoughts and behaviors.
High-risk participants will receive an evidence-based psychotherapy called the Collaborative Assessment and Management of Suicidality (CAMS). This therapeutic approach emphasizes collaboration between patient and clinician to identify and address the underlying drivers of suicidal thoughts, with a focus on increasing hope and reducing psychological distress. Neuroimaging and clinical assessments will be repeated after completion of CAMS to evaluate treatment-related changes.
The study's primary goals are to:
* Identify neural and electrophysiological correlates of suicide risk. * Distinguish biological differences between individuals with suicidal ideation and those who have attempted suicide. * Determine how CAMS therapy affects brain function and neurochemistry.
By integrating clinical and neurobiological data, this research aims to improve understanding of suicidality, enhance risk prediction, and inform more effective, personalized interventions for at-risk youth.
Inclusion: Subjects must be 14-24 years old; Subjects must be:; High Risk Subjects: Psychiatrically admitted due to a suicide attempt or history of 2 previous suicide attempts; Medium Risk Subjects: Suicide ideation for the past year with no suicide attempt; Minimal Risk Subjects: No previous history of suicidal ideation or behavior, not taking any psychiatric history or medication, and no family history of suicide; Subjects must have the ability to understand and the willingness to sign a written informed consent/assent document; Subjects must be English speaking.
Exclusion: Within 6 months before initial screening, urine toxicology positive for phencyclidine, cocaine or amphetamines (subjects prescribed amphetamines for the management of ADHD will not be excluded); Subjects with recent bone, tendon, spine or joint surgery; Subjects with recent metallic dental implants; Subjects with known history of Autism Spectrum Disorder; non-verbal patients; Subjects with Schizophrenia or history of any type of psychosis including mood related psychosis and brief reactive psychosis; Subjects with a history of moderate or severe substance or alcohol use per DSM-5 criteria in the past 6 months; Subjects with moderate or severe intellectual disability (IQ less than 70 and those patients in special education classes full time); Subjects who are currently pregnant or breastfeeding; Subjects in custody of Children's Services; Subjects weighing less than 30 kg or more than 200 kg.