Numbing Medicine in the Nose to Ease Pain From Botox Injections for Chronic Migraine
Tests lidocaine-soaked cotton in the nostrils to ease Botox injection pain in chronic migraine.
Plain-language title generated from the registry record
Registry title: Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine
Key facts
- Where
- East Providence, United StatesSee the site
Where in United States
- University OtolaryngologyEast Providence, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Association of Migraine Disorders
- Trial code
- NCT07571889
- Record updated
- 6 May 2026
- Original description
People find the injections used in onabotulinumtoxinA (Botox®) uncomfortable. This study will test whether putting a small piece of cotton soaked with 4% lidocaine (a numbing medicine) inside the front of each nostril for 5 minutes before the injections reduces injection pain compared with cotton soaked in saline (salt water).Read full original descriptionShow less
Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine: A Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Study
People find the injections used in onabotulinumtoxinA (Botox®) uncomfortable. This study will test whether putting a small piece of cotton soaked with 4% lidocaine (a numbing medicine) inside the front of each nostril for 5 minutes before the injections reduces injection pain compared with cotton soaked in saline (salt water).
Inclusion: Aged ≥18 years; Any gender; Able to provide informed consent; Meets clinical criteria for onabotulinumtoxinA for chronic migraine (minimum of 2 days of disability per month due to facial or headache pain, or 8 headache days per month, or more than 15 headaches per month); Scheduled for modified PREEMPT injections at the clinical site.
Exclusion: Trigeminal neuralgia, cluster headache, or other primary headache disorders as dominant diagnosis; Known allergy/hypersensitivity to lidocaine or amide anesthetics; Aged < 18 years; Not able to provide informed consent; Pregnancy/lactation; Inability to tolerate intranasal nasal cotton pledgets; Significant nasal pathology at placement site.