Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease
Key facts
- Where
- Aurora, United StatesSee the site
Where in United States
- University of Colorado Anschutz Medical CampusAurora, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Colorado, Denver
- Trial code
- NCT07576894
- Record updated
- 8 May 2026
- Original description
This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.Read full original descriptionShow less
Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease
This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.
Inclusion: COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity [FEV1/FVC] <0.7); Age >= 40 years.
Exclusion: Exacerbation of COPD in the 3 months prior to enrollment; Change in COPD therapy in the 3 weeks prior to enrollment; Known pulmonary hypertension with mean pulmonary artery pressure >45 mmHg; Untreated severe obstructive sleep apnea and/or obesity hypoventilation syndrome; Active malignancy (other than skin); Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance/gait instability, etc.); For subset undergoing right heart catheterization, chronic anticoagulation that is unable to be held for the study visit; For subset undergoing right heart catheterization or exercise training, forced expiratory volume in 1 second of <20%; For exercise training with an option for hybrid remote exercise training, any medical conditions which threaten the safety of remote exercise training (e.g. imbalance/gait instability, etc.); Active/uncontrolled cardiovascular disease (e.g. hypertension with blood pressure >150/100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; uncontrolled arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity); Requirement of >6 LPM supplemental oxygen at rest; Requirement of >10 LPM supplemental oxygen with exertion; Volume overload (jugular vascular distension or greater than trace peripheral edema); World Health Organization Functional Class IV; Pregnancy; Body mass index <18 or >35; Hematocrit <25% or >55%; For exercise training, already engaged in routine exercise training (>30 minutes at >3 METs 3 times/week or more); For exercise training, inability to complete initial in-person exercise training sessions for approximately 35 minutes 3x/week for 3 weeks (followed by exercise training sessions with an option for hybrid remote/in-person participation).