Macupatide and Eloralintide for Weight Loss in Adults With Obesity or Overweight
Tests macupatide and eloralintide, alone or together, in adults with overweight or obesity.
Plain-language title generated from the registry record
Registry title: A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
Key facts
- Where
- Amherst, Ammon, Austin, Chandler, Chicago, Cincinnati, City of Saint Peters, Dallas, Danville, Greenbrae, Greensboro, Greenville, Houston, Huntington Park, Las Vegas, Louisville, Miami, Miami Lakes, Monroe, Morehead City, Nashville, Needham, New Bedford, New Bern, New Port Richey, Orlando, Rochester, Rolling Hills Estates, San Antonio, Scottsdale, Southfield, Springfield, Stamford, The Villages, Topeka, Troy, Tucson, Walnut Creek, Wenatchee, and Weslaco, United StatesSee the 40 sites
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07589608, who can take part
Where in United States
- Dent Neurologic InstituteAmherst, United StatesTaking people
- Medical Research PartnersAmmon, United StatesTaking people
- IMA Clinical Research AustinAustin, United StatesTaking people
- The Institute for Liver Health II dba Arizona Clinical Trials - MesaChandler, United StatesTaking people
- Great Lakes Clinical Trials - RavenswoodChicago, United StatesTaking people
- CTI Clinical Research CenterCincinnati, United StatesTaking people
- StudyMetrix ResearchCity of Saint Peters, United StatesTaking people
- FutureSearch Trials of DallasDallas, United StatesTaking people
- Sovah Clinical Research-River DistrictDanville, United StatesTaking people
- NorCal Medical Research, IncGreenbrae, United StatesTaking people
- Medication ManagementGreensboro, United StatesTaking people
- Tribe Clinical Research LLCGreenville, United StatesTaking people
- PlanIt Research, PLLCHouston, United StatesTaking people
- Velocity Clinical Research-Huntington ParkHuntington Park, United StatesTaking people
- Las Vegas Medical ResearchLas Vegas, United StatesTaking people
- Monroe Biomedical Research - LouisvilleLouisville, United StatesTaking people
- New Horizon Research CenterMiami, United StatesTaking people
- Indago Research & Health Center, IncMiami Lakes, United StatesTaking people
- Monroe Biomedical ResearchMonroe, United StatesTaking people
- Lucas Research, Inc.Morehead City, United StatesTaking people
- Quality Medical ResearchNashville, United StatesTaking people
- KnownwellNeedham, United StatesTaking people
- Lucida Clinical TrialsNew Bedford, United StatesTaking people
- Lucas Research, Inc.New Bern, United StatesTaking people
- Suncoast Clinical Research, Inc.New Port Richey, United StatesTaking people
- Charter Research - Winter ParkOrlando, United StatesTaking people
- Rochester Clinical Research, LLCRochester, United StatesTaking people
- Peninsula Research AssociatesRolling Hills Estates, United StatesTaking people
- Endeavor Clinical TrialsSan Antonio, United StatesTaking people
- Headlands Research - ScottsdaleScottsdale, United StatesTaking people
- Headlands Research - DetroitSouthfield, United StatesTaking people
- Clinvest Headlands LLCSpringfield, United StatesTaking people
- Stamford Therapeutics ConsortiumStamford, United StatesTaking people
- Charter Research - Lady LakeThe Villages, United StatesTaking people
- Cotton O'Neil Diabetes & EndocrinologyTopeka, United StatesTaking people
- Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroy, United StatesTaking people
- The Institute for Liver Health II dba Arizona Liver Health-TucsonTucson, United StatesTaking people
- Diablo Clinical Research, Inc.Walnut Creek, United StatesTaking people
- Central Washington Health Services Association d/b/a Confluence HealthWenatchee, United StatesTaking people
- Texas Valley Clinical ResearchWeslaco, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Eli Lilly and Company
- Trial code
- NCT07589608
- Record updated
- 8 October 2026
- Original description
The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.Read full original descriptionShow less
A Phase 2b, Parallel-Group, Double-Blind, Placebo-Controlled Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight and Without Type 2 Diabetes
The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.
Inclusion: See Master Protocol CWMM (NCT06143956) for inclusion criteria.
Exclusion: All concomitant medications should be at a stable dose for at least 3 months prior to screening; Have type 1 diabetes or type 2 diabetes; Have an ongoing history of bradyarrhythmia and/or sinus bradycardia; Have a history of acute or chronic pancreatitis; In addition to exclusion criteria in Master Protocol CWMM (NCT06143956):; Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm).