Sodium butyrate and yeast supplement for ulcerative colitis in remission
Tests the ButyMixx supplement for safety in adults with ulcerative colitis in remission.
Plain-language title generated from the registry record
Registry title: Sodium Butyrate and Kluyveromyces Marxianus Supplementation in Inflammatory Bowel Disease
Key facts
- Where
- Padova, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07591012, who can take part
Where in Italy
- Edoardo SavarinoPadova, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Padova
- Trial code
- NCT07591012
- Record updated
- 15 May 2026
- Original description
The goal of this clinical trial is to learn if a dietary supplement called ButyMixx can help people with ulcerative colitis in remission feel better and keep their intestines less inflamed.Read full original descriptionShow less
Safety and Tolerability of Sodium Butyrate and Kluyveromyces Marxianus Supplementation in Inflammatory Bowel Disease Treatment
The goal of this clinical trial is to learn if a dietary supplement called ButyMixx can help people with ulcerative colitis in remission feel better and keep their intestines less inflamed.
ButyMixx contains:
* Sodium butyrate, a substance normally produced by our gut microbiota that helps protect the intestinal lining and reduce inflammation. * A "beneficial" yeast (Kluyveromyces marxianus), similar to probiotics, which may support the balance of the intestinal microbiota.
It will also learn about the safety of dietary supplement. The main questions it aims to answer are:
* Does ButyMixx after 2 months of supplementation
* Symptoms improve, * Quality of life improves, * Intestinal inflammation decreases , * The gut microbiota becomes more "balanced" * What medical problems do participants have when taking ButyMixx ?
Participants will:
* Take 2 sachets of ButyMixx per day for 8 weeks * Before starting and at the end of the 8 weeks:
* Provide a stool sample * Complete a quality-of-life questionnaire * Be assessed by a doctor using a symptom score
Inclusion: Diagnosis of UC confirmed by clinical, endoscopic and histopathological evidence. Disease in remission phase confirmed by clinical, endoscopic and histopathological evidence; Age between 18 and 75 years old; Ability of subject to participate fully in all aspects of this clinical trial.
Exclusion: Patients under antibiotic and/or probiotic treatment within 10 days prior to Visit 1; Known diagnosis of CD( Crohn disease), indeterminate colitis, ischemic colitis, radiation colitis, diverticular disease associated with colitis or microscopic colitis; Patients that have active UC, determined by clinical, endoscopic and histopathological evidence; Positive stool culture for active C. difficile; Pregnant women.