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Computer-based brain training for older adults, with and without mild cognitive impairment

Tests computer brain training in older adults, some with MCI.

Key facts

Who runs it
Universidad Antonio de Nebrija
Where
Spain2 sites in 1 countryChoose a country to see its sites
Trial code
Registry title
Computerized Cognitive Training in Healthy Older Adults and Mild Cognitive Impairment
Status
Recruiting
People taking part
156 people, planned
Started
4 Jun 2025
Expected to end
Aug 2028
Type of study
Interventional, 4 groupsOne group gets a placebo (a dummy treatment), for comparison.
Treatments tested
  • Computerized Cognitive Training
  • Active Control Computerized Activities
Record updated
20 May 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for Spanish-speaking older adults living in Spain, either healthy or with mild cognitive impairment (mild memory and thinking problems), to test computer brain training.

Age
65 years and older
Sex
All sexes
Disease stage
Healthy older adults or people with mild cognitive impairment, without dementia. Thinking skills are checked with a screening test (the Spanish version of the MMSE).

Main reasons for not taking part

  • Diagnosis of dementia, such as Alzheimer's disease, or test scores that suggest severe impairment or early dementia
  • Uncontrolled active major mental illness, such as major depression or schizophrenia
  • Significant uncontrolled brain or nerve conditions, such as Parkinson's disease, stroke or severe brain injury
  • Uncontrolled long-term illnesses, such as diabetes or heart disease, that may affect thinking or attending sessions
  • Severe uncorrected vision or hearing loss that makes tablet tasks impossible

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

  • adults 65 years of age and older
  • spanish speakers
  • residents in Spain (urban and rural communities)
  • elderly population that does not have dementia or other major diagnosed uncontrolled neurological disorders
  • the initial cognitive state will be determined by a global screening test, the Lobo's Mini Cognitive Examination, that is, the spanish version of the Mini-Mental State Examination (MMSE); and 6) all participants must provide their signed written informed consent indicating that the individual has been informed of the relevant aspects of the study (and may withdraw from the study at any time if they so request)

Who cannot take part

  • Older adults who obtain scores indicative of severe impairment (to be determined for low MEC scores that are suggestive of incipient dementia) or whose medical condition prevents them from participating safely
  • diagnosis of dementia (e.g., Alzheimer's disease or other)
  • uncontrolled active major psychiatric illness (major depression, schizophrenia, etc.)
  • significant uncontrolled neurological conditions or history (e.g., Parkinson's disease, stroke, severe traumatic brain injury)
  • uncontrolled decompensated chronic medical conditions (e.g., diabetes, cardiovascular disease) that may affect cognition or attendance at sessions; and 6) severe uncorrected sensory disabilities (e.g., blindness or severe hearing loss) that interfere with the performance of tasks on tablets

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The overall objective of this study is to assess the effect of an adaptive computerized cognitive training program for executive functions (CogniFit platform) on improving these functions in older adults, both healthy and with mild cognitive impairment (MCI), as well as to examine the potential transfer effects of this training on memory. Additionally, determine the impact of the intervention on the emotional symptoms, behavioral disorders, or quality of life of the participants.

The 4 groups in the trial

  • Group 1. Cognitively healthy older adults assigned to active control activities.Placebo, for comparison

    Treatment: Active Control Computerized Activities

  • Group 2. Cognitively healthy older adults assigned to executive function cognitive training.Treatment being tested

    Treatment: Computerized Cognitive Training

  • Group 3. Older adults with MCI assigned to active control activities.Placebo, for comparison

    Treatment: Active Control Computerized Activities

  • Group 4. Older adults with MCI assigned to cognitive training of executive functions.Treatment being tested

    Treatment: Computerized Cognitive Training

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Computerized Executive Function Training in Healthy Older Adults and Individuals With Mild Cognitive Impairment: Transfer Effects on Memory and Emotional Outcomes. A Randomized Controlled Trial
Plain-language title
Computer-based brain training for older adults, with and without mild cognitive impairmentGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 15 November 2026.
Record updated
20 May 2026