Tests a new CT scan for measuring laryngeal cancer spread before surgery
Tests a new CT scanning method in adults with laryngeal cancer before surgery.
Plain-language title generated from the registry record
Registry title: p-PHOTOLARYNX- ANTHEM: Photon-Counting CT in Laryngeal Cancer Staging
Key facts
- Where
- Rozzano, ItalySee the site
Where in Italy
- Humanitas Research HospitalRozzano, ItalyNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Humanitas University
- Trial code
- NCT07603167
- Record updated
- 22 May 2026
- Original description
Laryngeal cancer can affect speaking, swallowing, and breathing. Treatment selection depends on accurately defining tumor spread within the larynx, particularly invasion of the paraglottic space, thyroid cartilage, and subglottic region. Understaging may lead to insufficient treatment and recurrence, whereas overstaging may result in unnecessarily aggressive surgery and impaired quality of life.Read full original descriptionShow less
p-PHOTOLARYNX- ANTHEM: Pilot Photon-Counting CT Evaluation of the Paraglottic Space and Cartilage Involvement in Laryngeal Cancer
Laryngeal cancer can affect speaking, swallowing, and breathing. Treatment selection depends on accurately defining tumor spread within the larynx, particularly invasion of the paraglottic space, thyroid cartilage, and subglottic region. Understaging may lead to insufficient treatment and recurrence, whereas overstaging may result in unnecessarily aggressive surgery and impaired quality of life.
CT and MRI are routinely used for local staging, but both have limitations. Conventional CT may have limited soft-tissue and cartilage contrast, while MRI is more time-consuming, motion-sensitive, and not feasible in all patients. Photon-counting CT (PCCT) is a new CT technology offering higher spatial resolution, improved tissue contrast, and reconstructions at different energy levels.
This study evaluates whether PCCT performed during phonation, while the patient produces a sustained sound, can improve local staging of laryngeal cancer. Phonation may better separate and display laryngeal structures, improving detection of tumor extension.
The main hypothesis is that optimized phonation PCCT reconstructions can assess tumor spread more accurately than standard CT and may approach MRI performance. Participants undergo PCCT as part of routine preoperative imaging. Images are reconstructed using different settings and reviewed by radiologists for image quality and tumor extension. When surgery is performed, imaging findings are compared with surgical and histopathological results.
The study aims to identify the most accurate PCCT reconstruction strategy to support better treatment planning in laryngeal cancer.
Inclusion: Adults (≥18 years); Biopsy-proven laryngeal cancer squamous cell carcinoma; Candidate for surgical staging able to undergo PCCT.
Exclusion: Renal failure; Allergy to contrast medium; Refusal of informed consent; Lack of histopathologic confirmation; Histopathologic diagnosis of non laryngeal tumors; Poor image quality due to severe artifacts.
SELECTION CRITERIA.