Gum Disease Treatment and Gene Changes in People With and Without Obesity
Studies how deep cleaning changes gene activity in adults with gum disease.
Key facts
- Who runs it
- Louisiana State University Health Sciences Center in New Orleans
- Where
- New Orleans, United StatesSee the site
- Trial code
- Registry title
- Periodontal Inflammation and Epigenetics in Obese Individuals
- Status
- Not yet recruiting
- People taking part
- 40 people, planned
- Started
- 25 May 2026
- Expected to end
- 30 Dec 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Non-surgical periodontal therapy will be administered
- Record updated
- 28 May 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with gum disease (periodontitis), some who are obese and some who are not. It studies how deep cleaning of the gums changes the body's gene switches over time.
- Age
- 18 Years to 75 Years
- Sex
- All
- Disease stage
- Periodontitis (gum disease), in people who are obese or not obese. At least 20 teeth are needed.
- Earlier treatment
- No gum treatment in the last 6 months. No antimicrobial or antiviral treatment in the previous 3 months. No current weight loss drugs.
Main reasons for not taking part
- Tobacco use
- Uncontrolled diabetes, rheumatoid arthritis, osteoporosis or oral cancer
- Pregnant or breastfeeding now or in the prior 6 months, or taking hormonal contraception
- Planning weight reduction surgery during the study
- Any other condition or therapy known to affect mouth inflammation or mouth bacteria
The registry criteria, word for word
Show all 15 criteriaShow less
Who can take part
- Adults aged ≥18 years,
- No history of periodontal therapy in the last 6 months,
- No use of tobacco,
- No history of pregnancy lactation or contraceptive medication
- Need to have a minimum of 20 teeth
Who cannot take part
- Had antimicrobial/antiviral therapy in the previous 3 months,
- Currently taking hormonal contraception,
- If pregnant or lactating currently or prior 6 months,
- Subjects on current weight loss drugs
- If planning weight reduction surgery during the time of the study
- History of uncontrolled diabetes,
- History of rheumatoid arthritis,
- History of osteoporosis,
- History of oral cancer,
- Any other condition, disease or therapy with documented influence on oral inflammation and/or oral microbial environment
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Where in United States
- LSU Health Science Centre, School of DentistryNew Orleans, United StatesContact: Vinayak M Joshi, PhD, MSNot yet recruiting
About the trial
What the trial wants to find out
The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis. The aims of the study are:
Read full original descriptionShow less
• To monitor longitudinal changes in host epigenetic modifiers following non-surgical periodontal therapy in periodontitis patients Study subjects would be categorized into two groups, non-obese with periodontitis, and obese with periodontitis. The study will primarily evaluate changes among these groups cross-sectionally, then longitudinally following non-surgical periodontal therapy (deep cleaning) to determine if any changes occur with treatment.
The 2 groups in the trial
- non-obese with periodontitisExisting treatment, for comparison
Non-surgical periodontal therapy will be administered
Treatment: Non-surgical periodontal therapy will be administered
- obese with periodontitisExisting treatment, for comparison
Non-surgical periodontal therapy will be administered
Treatment: Non-surgical periodontal therapy will be administered
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Association Between Epigenetic Changes, Periodontal Microbiota, And Periodontal Inflammation in Obese Individuals
- Plain-language title
- Gum Disease Treatment and Gene Changes in People With and Without ObesityGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 13 November 2026.
- Fit questions
- Built from NCT07610902, who can take part
- Record updated
- 28 May 2026