Prednisone after knee replacement surgery and its effect on blood sugar
Tests prednisone after joint replacement in adults with osteoarthritis, tracking pain and blood sugar.
Key facts
- Who runs it
- Columbia University
- Where
- New York, United StatesSee the site
- Trial code
- Registry title
- Post-op Prednisone and Glucose Monitoring in TKA
- Status
- Recruiting
- Phase
- Phase 4
- People taking part
- 104 people, planned
- Started
- 22 Jun 2026
- Expected to end
- Mar 2028
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Prednisone
- Continuous Glucose Monitor
- InkWell Health Tattoos
- Record updated
- 2 October 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults having a first partial knee replacement or total hip replacement at Columbia University Irving Medical Center, done by Dr. Roshan P. Shah. You can only take part if the study team contacts you. The trial does not take applications.
- Age
- 18 years and older
- Sex
- All sexes
- Disease stage
- People having a planned first (primary) unicompartmental knee arthroplasty (partial knee replacement) or total hip arthroplasty (hip replacement).
- Earlier treatment
- People who are on steroid therapy cannot join. People who used narcotic pain medicines in the past 3 months cannot join.
Main reasons for not taking part
- Steroid therapy or narcotic use within the past 3 months
- Past intolerance to corticosteroids
- Pregnancy
- Diabetes that is not under control
- Not owning a smart phone
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- MUST BE CONTACTED BY THE STUDY TEAM TO BE PART OF THE STUDY. No applications taken
- Undergoing Primary Unicompartmental Knee Arthroplasty or Total Hip Arthroplasty
- Age 18 and above
- Patient at Columbia University Irving Medical Center and be undergoing planned surgery by Dr. Roshan P. Shah
Who cannot take part
- Steroid therapy
- 2nd dose of IV dexamethasone
- History of corticosteroid intolerance
- Uncontrolled diabetes
- Narcotic use within past 3 months
- Pregnancy
- Doesn't own smart phone; Drop Criteria:
Where in United States
- Columbia University Irving Medical CenterNew York, United StatesContact: Roshan Shah, MDTaking people
About the trial
What the trial wants to find out
This study compares the efficacy of a 5-day post-operative oral prednisone regimen (40 mg daily) with the standard intraoperative steroid regimen, focusing on pain, swelling, range of motion, opioid use, and glucose levels monitored continuously.
The 2 groups in the trial
- Post-operative SteroidsExisting treatment, for comparison
Participants will receive a 5-day regimen of 40 mg oral prednisone postoperatively.
Treatment: Prednisone, Continuous Glucose Monitor, and InkWell Health Tattoos
- Standard of carePlacebo, for comparison
Participants will receive standard of care treatment, consisting of the intravenous administration of dexamethasone and periarticular administration of steroids intraoperatively.
Treatment: Continuous Glucose Monitor and InkWell Health Tattoos
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Postoperative Prednisone Regimen in TKA and Its Effect on Continuous Glucose Levels
- Plain-language title
- Prednisone after knee replacement surgery and its effect on blood sugarGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Record updated
- 2 October 2026