Extra Fluid Removal During Dialysis for People With Kidney Failure
Tests extra ultrafiltration to remove excess body fluid in adults on hemodialysis.
Plain-language title generated from the registry record
Registry title: Dry Weight Reduction Intervention Via Extra Ultrafiltration
Key facts
- Where
- Seattle, United StatesSee the site
Where in United States
- Northwest Kidney CentersSeattle, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Washington
- Trial code
- NCT07637110
- Record updated
- 30 October 2026
- Original description
Most patients who receive hemodialysis treatments have excess fluid in their body that has slowly built up over the course of kidney disease. This extra fluid is the main cause of high blood pressure in dialysis and leads to stress on the heart and lungs.that causes debilitating symptoms and frequent hospitalizations.Read full original descriptionShow less
Dry Weight Reduction Intervention Via Extra Ultrafiltration
Most patients who receive hemodialysis treatments have excess fluid in their body that has slowly built up over the course of kidney disease. This extra fluid is the main cause of high blood pressure in dialysis and leads to stress on the heart and lungs.that causes debilitating symptoms and frequent hospitalizations.
This trial will test whether a focused program of 4 or 8 weeks of extra ultrafiltration treatments can remove most of this extra fluid. We believe that getting rid of large amounts of extra fluid will result in sustained improvements in blood pressure and symptoms. Ultrafiltration is a gentler type of dialysis that removes fluid but does not clean the blood.
Inclusion: Receiving thrice weekly in-center hemodialysis treatments for end stage kidney disease for at least four weeks and clinical suspicion of volume excess based on either:; Persistent hypertension defined by three consecutive pre-dialysis systolic blood pressures ≥140 mmHg or three consecutive pre-dialysis systolic blood pressures 130-140 mmHg plus use of at least two anti-hypertensive medications that can be tapered; OR; Symptoms of congestion defined by a 12-item Kidney Modified Kansas City Cardiomyopathy Questionnaire (KM-KCCQ) score <75.
Exclusion: Receiving hemodialysis treatments for acute kidney injury; Receiving hemodialysis treatments for less than four weeks; Scheduled kidney transplantation; Major cardiovascular or bleeding event within previous 90 days; Receiving chemotherapy or radiation treatment for cancer; History of cirrhosis with ascites; History of non-adherence with dialysis treatments; Age <18 years; Planned switch to peritoneal or home dialysis within next three months; Current or planned incremental hemodialysis (less than 3 treatments per week); Current or planned intensive hemodialysis (four or more treatments per week); Inability to complete 24-hour ambulatory blood pressure measurement; Wheelchair dependance or other inability to complete six-minute walk test; Pre-dialysis systolic blood pressure <100 mmHg; Scheduled use of midodrine with hemodialysis treatments; Pregnancy; Institutionalized; Current or pending enrollment in hospice care; Inappropriate for enrollment based on investigator or nephrologist discretion.