How Insulin Affects Blood Vessels and the Brain in People With Obesity
Tests how insulin acts on the brain and blood vessels in adults with obesity.
Plain-language title generated from the registry record
Registry title: Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity
Key facts
- Where
- Columbia, United StatesSee the site
- Phase
- Early phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07653464, who can take part
Where in United States
- University of MissouriColumbia, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Missouri-Columbia
- Trial code
- NCT07653464
- Record updated
- 15 October 2026
- Original description
Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.Read full original descriptionShow less
Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity
Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.
Inclusion: 18 to 65 years of age; Individuals with obesity and comorbid IR; BMI 30-45 kg/m2; Waist circumference ≥102 cm (men) or ≥88 cm (women); HOMA-IR ≥2.5; Healthy normal weight adults; BMI 18-25 kg/m2; Waist circumference <94 cm (men) and <80 cm (women); HOMA-IR <2.
Exclusion: Use of pharmacological therapy for weight loss; Participation in any other research study or medical procedure involving significant ionizing radiation exposure in the past 12 months; Non-MRI compatible metal implants; Diabetes or polycystic ovarian syndrome; Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease, stroke; Nerve/neurologic disease; Uncontrolled hypertension (systolic blood pressure >180 mmHg and/or diastolic blood pressure >100 mmHg); Active cancer (excluding basal cell carcinoma or stage 1 squamous cell carcinoma of the skin); Pregnancy, breastfeeding; Unable to provide consent; Current smoking, tobacco, nicotine use; Body weight change >10% within the last 6 months; Adherence to >150 min/week of moderate-to-vigorous physical activity/exercise; Claustrophobia.