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Taking people in United StatesPhase 3

Study to Determine if BHV-1300 is Effective and Safe in Adults With Graves' Disease

Key facts

Where
Albuquerque, Amarillo, Asheville, Atlanta, Baton Rouge, Burbank, Canton, Champaign, Chattanooga, Cincinnati, Dallas, Denton, Doral, El Paso, Farmington Hills, Fayetteville, Fort Myers, Greenville, Hialeah, Hollywood, Houston, Huntington Beach, Kansas City, La Jolla, Las Vegas, Layton, Lenexa, McKinney, Memphis, Miami, Midlothian, Morehead City, Norman, North Charleston, Oak Brook, Oakland, Orchard Park, Palm Beach Gardens, Philadelphia, Raleigh, San Antonio, San Diego, Seattle, Shavano Park, South Gate, Springfield, St Louis, Statesville, Tampa, Tucson, Walnut Creek, Washington D.C., Weslaco, and Wilmington, United StatesSee the 57 sites
Phase
Phase 3

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 70 years old?

Source: NCT07661056, who can take part

Where in United States

  • Albuquerque, New MexicoHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Amarillo, TexasHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Asheville, North CarolinaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Atlanta, GeorgiaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Baton Rouge, LouisianaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Burbank, CaliforniaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Canton, OhioHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Champaign, IllinoisHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Chattanooga, TennesseeHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Cincinnati, OhioHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Dallas, TexasHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Dallas, TexasHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Denton, TexasHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Doral, FloridaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • El Paso, TexasHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Farmington Hills, MichiganHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Fayetteville, GeorgiaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Fort Myers, FloridaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Greenville, North CarolinaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Hialeah, FloridaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Hollywood, FloridaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Houston, TexasHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Houston, TexasHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Huntington Beach, CaliforniaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Kansas City, MissouriHospital not named in the registryContact: Chief Medical OfficerTaking people
  • La Jolla, CaliforniaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Las Vegas, NevadaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Layton, UtahHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Lenexa, KansasHospital not named in the registryContact: Chief Medical OfficerTaking people
  • McKinney, TexasHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Memphis, TennesseeHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Miami, FloridaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Midlothian, VirginiaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Morehead City, North CarolinaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Morehead City, North CarolinaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Norman, OklahomaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • North Charleston, South CarolinaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Oak Brook, IllinoisHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Oakland, CaliforniaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Orchard Park, New YorkHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Palm Beach Gardens, FloridaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Philadelphia, PennsylvaniaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Raleigh, North CarolinaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • San Antonio, TexasHospital not named in the registryContact: Chief Medical OfficerTaking people
  • San Diego, CaliforniaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Seattle, WashingtonHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Shavano Park, TexasHospital not named in the registryContact: Chief Medical OfficerTaking people
  • South Gate, CaliforniaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Springfield, IllinoisHospital not named in the registryContact: Chief Medical OfficerTaking people
  • St Louis, MissouriHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Statesville, North CarolinaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Tampa, FloridaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Tucson, ArizonaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Walnut Creek, CaliforniaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Washington D.C., District of ColumbiaHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Weslaco, TexasHospital not named in the registryContact: Chief Medical OfficerTaking people
  • Wilmington, North CarolinaHospital not named in the registryContact: Chief Medical OfficerTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
Biohaven Therapeutics Ltd.
Trial code
NCT07661056EU 2026-526455-53-00
Record updated
12 November 2026
Original description
The purpose of this study is to evaluate the efficacy and safety of BHV-1300 in adult participants with Graves' disease who are actively hyperthyroidRead full original descriptionShow less

A Phase 3, Double-blind, Multicenter, Randomized, Placebo-Controlled Study to Evaluate the Efficacy, Safety and Tolerability of BHV-1300 in the Treatment of Adults With Graves' Disease

The purpose of this study is to evaluate the efficacy and safety of BHV-1300 in adult participants with Graves' disease who are actively hyperthyroid

Inclusion: Participants must have serologically confirmed Graves' disease as documented by presence of elevated autoantibodies; Participants must have active hyperthyroidism due to Graves' disease.

Exclusion: History of treatment with radioactive iodine or thyroid surgery; Have received levothyroxine, desiccated thyroid extract, or T3 at any dose within six weeks of the Baseline/Day 1 Visit; Are expected to require urgent or emergent thyroid surgery or ablation within six weeks of Baseline/Day 1 or throughout the study; History of hyperthyroidism not caused by Graves' Disease (e.g., toxic adenoma or toxic multinodular goiter); Thyroid storm, i.e. severe thyrotoxicosis with evidence of systemic decompensation (e.g., Burch-Wartkofsky Point Scale of ≥ 45 or Japanese Thyroid Association category 1 or 2, with accompanying manifestations including hyperpyrexia, tachycardia, arrhythmias, congestive heart failure, agitation, delirium, psychosis, stupor, and coma, as well as nausea, vomiting, diarrhea, or hepatic failure) within 6 weeks of Screening; Have autoimmune disease other than Graves' disease requiring treatment; Have moderate to severe thyroid eye disease (TED) or are expected to require immediate surgical intervention and/or are planning corrective surgery/irradiation or medical therapy for TED during study participation.

ClinicalTrials.gov NCT07661056 · EU CTIS 2026-526455-53-00