Olive oil mouthwash to clear leftover inhaled asthma medicine from the mouth
Compares an olive oil mouthwash with water for clearing fluticasone propionate in adults with asthma.
Plain-language title generated from the registry record
Registry title: Novel Method for Removal of Orally Deposited Inhaled Fluticasone Propionate
Key facts
- Where
- Madison, United StatesSee the site
- Phase
- Phase 4
Where in United States
- University of WisconsinMadison, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Wisconsin, Madison
- Trial code
- NCT07664527
- Record updated
- 5 November 2026
- Original description
This study aims to determine whether an extra virgin olive oil-based water (EVOOW) mixture removes more fluticasone propionate (FP) from the mouth than water alone. More effective removal of residual FP deposits may help reduce the risk of complications associated with inhaled corticosteroid use, including obstructive sleep apnea (OSA), oral candidiasis (thrush), and speech and swallowing dysfunction.Read full original descriptionShow less
A Proof-of-Concept Study of a Novel Method for Removal of Residual Oropharyngeal Inhaled Corticosteroid Deposits in Asthma
This study aims to determine whether an extra virgin olive oil-based water (EVOOW) mixture removes more fluticasone propionate (FP) from the mouth than water alone. More effective removal of residual FP deposits may help reduce the risk of complications associated with inhaled corticosteroid use, including obstructive sleep apnea (OSA), oral candidiasis (thrush), and speech and swallowing dysfunction.
Participants will attend two separate testing visits, during which they will rinse and gargle with either EVOOW or water, after receiving 1 puff if fluticasone propionate. The visits will be scheduled 7-10 days apart. Total participation will last up to 3 weeks.
Inclusion: Healthy adults and adults with asthma, age 18 years and older; Willing to hold orally and nasally inhaled corticosteroids (ICS) for 24h and 12h, respectively, before study visits with mouthwash sample collections (Visit 2 and Visit 3); No systemic or topical ocular corticosteroid use for the prior 4 weeks.
Exclusion: Known hypersensitivity to fluticasone propionate; Allergy to olives or olive oil; Known allergy to oxymetazoline; Current smoking or vaping; Currently pregnant or trying to become pregnant.