Following adults with obesity to learn how the condition develops and treatment response
Reviews past and future records of adults with obesity or overweight to study treatment outcomes.
Key facts
- Who runs it
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Where
- Bologna, ItalySee the site
- Trial code
- Registry title
- ASSESSMENT OF THE NATURAL HISTORY AND PROGNOSTIC FACTORS OF THERAPEUTIC RESPONSE IN SUB-PHENOTYPES OF PATIENTS WITH OBESITY: THE BOLOBE STUDY
- Status
- Recruiting
- People taking part
- 10,000 people, planned
- Started
- 30 May 2026
- Expected to end
- Mar 2038
- Type of study
- Observational
- Record updated
- 24 June 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with obesity, or with overweight and a heart or metabolic health problem. It collects their health data and follows how they respond to treatment.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- BMI of 30 kg/m² or more, or BMI of 25 kg/m² or more with at least one cardiometabolic comorbidity
Main reasons for not taking part
- Obesity caused by hypothalamic-pituitary disorders
- Obesity caused by adrenal disorders
- Syndromic obesity
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Age ≥ 18 years
- Body mass index (BMI) ≥ 30 kg/m², or BMI ≥ 25 kg/m² with at least one cardiometabolic comorbidity
- Provision of written informed consent
Who cannot take part
- Obesity secondary to hypothalamic-pituitary disorders
- Obesity secondary to adrenal disorders
- Syndromic obesity
Where in Italy
- IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna, ItalyContact: Maria Letizia Petroni, MDTaking people
About the trial
What the trial wants to find out
The study is observational and single-center and involves (i) the establishment of a retrospective and prospective data collection, and (ii) the development of prognostic and predictive models of response to obesity therapies using statistical modeling and machine learning techniques, exclusively for research purposes.
Read full original descriptionShow less
Data collection will be carried out for each patient diagnosed with obesity or overweight whose first visit to the center occurred from January 1, 2000 up to the start of the study, as well as for patients accessing the center during the subsequent 5 years, including patients who died or were lost to follow-up.
With respect to the primary objective, an interim analysis is planned on the retrospective cohort only, once the collection of data already available at study start has been completed for patients with at least 5 years of follow-up.
Data related to instrumental and laboratory examinations and therapeutic interventions, including pharmacological treatments and group-based educational and behavioral therapies, conducted in accordance with routine clinical practice and the most recent relevant national and international guidelines, will be extracted from the electronic health records routinely used at the study center.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- ASSESSMENT OF THE NATURAL HISTORY AND PROGNOSTIC FACTORS OF THERAPEUTIC RESPONSE IN SUB-PHENOTYPES OF PATIENTS WITH OBESITY: THE BOLOBE STUDY (BOLOgna for OBEsity Follow-up BOLOBE)
- Plain-language title
- Following adults with obesity to learn how the condition develops and treatment responseGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 24 June 2026