Zenagamtide compared with semaglutide for weight loss in adults with obesity
Compares zenagamtide with semaglutide for weight loss in adults with excess body weight.
Plain-language title generated from the registry record
Registry title: A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide
Key facts
- Where
- Amarillo, Atlanta, Austin, Brownsville, Charleston, Chicago, Corpus Christi, Dallas, Danville, DeSoto, Fargo, Greensboro, Hollywood, Houston, Indianapolis, Jacksonville, Lancaster, Miami, Miramar, Naples, Orlando, Oviedo, Palm Springs, Pomona, Renton, Richmond, Roanoke, San Antonio, San Diego, Seattle, Simpsonville, Skokie, Snellville, Spartanburg, St Louis, Statesville, Sugar Land, Syracuse, Washington D.C., West Palm Beach, West Seneca, Weston, and Zachary, United StatesSee the 45 sites
- Phase
- Phase 3
Where in United States
- Amarillo Med Spec LLPAmarillo, United StatesTaking people
- Conquest ResearchAtlanta, United StatesTaking people
- Texas Diabetes & EndocrinologyAustin, United StatesTaking people
- Pinnacle Clinical ResearchBrownsville, United StatesTaking people
- Medical University of South CarolinaCharleston, United StatesTaking people
- Chicago Research Center Inc.Chicago, United StatesNot yet recruiting
- Osvaldo A. Brusco MDCorpus Christi, United StatesTaking people
- UT Southwestern Med CenterDallas, United StatesNot yet recruiting
- Geisinger ClinicDanville, United StatesTaking people
- Epic Medical ResearchDeSoto, United StatesNot yet recruiting
- Lillestol Research, LLCFargo, United StatesTaking people
- PharmQuest Life Sciences LLCGreensboro, United StatesNot yet recruiting
- Encore Medical Research LLCHollywood, United StatesTaking people
- NextPhase ResearchHollywood, United StatesTaking people
- Houston Research InstituteHouston, United StatesNot yet recruiting
- The Endocrine CenterHouston, United StatesNot yet recruiting
- Midwest Inst For Clin ResIndianapolis, United StatesTaking people
- Jacksonville Ctr Clin ResJacksonville, United StatesNot yet recruiting
- First Valley Medical GroupLancaster, United StatesTaking people
- PharmaDev Clinical Research Institute, LLCMiami, United StatesTaking people
- South Broward Research LLCMiramar, United StatesTaking people
- Essence MD ResearchNaples, United StatesNot yet recruiting
- Florida Inst For Clin Res LLCOrlando, United StatesTaking people
- Oviedo Medical Research, LLCOviedo, United StatesTaking people
- Desert Oasis HealthcarePalm Springs, United StatesTaking people
- Western University of Health SciencesPomona, United StatesTaking people
- Rainier Clin Res Ctr IncRenton, United StatesTaking people
- National Clin Res Inc.Richmond, United StatesTaking people
- Gastroent Consult of SW VARoanoke, United StatesNot yet recruiting
- Sleep Therapy Research CenterSan Antonio, United StatesNot yet recruiting
- Artemis Insitute for Clin ResSan Diego, United StatesTaking people
- Seattle Clinical Research CenterSeattle, United StatesTaking people
- Hillcrest Clinical ResearchSimpsonville, United StatesTaking people
- Endeavor HealthSkokie, United StatesTaking people
- Eastside Bariatric and Gen SurgSnellville, United StatesTaking people
- Spartanburg Medical ResearchSpartanburg, United StatesTaking people
- Amicis Centers of Clinical ResearchSt Louis, United StatesTaking people
- Piedmont Healthcare/ResearchStatesville, United StatesTaking people
- Olympus Clinical ResearchSugar Land, United StatesNot yet recruiting
- Ichor ResearchSyracuse, United StatesTaking people
- Med Home Development GrpWashington D.C., United StatesTaking people
- Palm Beach Research CenterWest Palm Beach, United StatesTaking people
- Southgate Medical Group, LLPWest Seneca, United StatesTaking people
- Encore Medical Research of WestonWeston, United StatesTaking people
- Southern Clin ResearchZachary, United StatesNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Novo Nordisk A/S
- Trial code
- NCT07668414
- Record updated
- 28 September 2026
- Original description
The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.Read full original descriptionShow less
Efficacy and Safety of Zenagamtide s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Obesity (AMAZE 7)
The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.
Inclusion: Male or female (sex at birth); Age 18 years or above at the time of signing the informed consent.
Exclusion: Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues within 1 year before screening; History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records; Glycated haemoglobin (HbA1c) ≥ 6.5% (48 millimoles per mole [mmol/mol]) as measured by the central laboratory at screening.