Pulmonary hypertension in people on hemodialysis when fluid levels are balanced
Looks at lung blood pressure problems in adults on hemodialysis for kidney failure.
Plain-language title generated from the registry record
Registry title: Euvolemia-Based Assessment of Pulmonary Hypertension in Stable Hemodialysis Patients
Key facts
- Where
- Bucharest, RomaniaSee the 2 sites
Where in Romania
- Fundeni Clinical InstituteBucharest, RomaniaNo longer taking part
- Institute for Cardiovascular Diseases C.C. IliescuBucharest, RomaniaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Stefan Lujinschi
- Trial code
- NCT07676786
- Record updated
- 30 June 2026
- Original description
Pulmonary hypertension (PH) is a frequent and clinically significant complication in patients with end-stage kidney disease (ESKD) undergoing maintenance hemodialysis (HD). However, PH assessment in this population is often confounded by volume overload, leading to potential overestimation and misclassification.Read full original descriptionShow less
Prospective Observational Study on Predictors and Types of Pulmonary Hypertension in Euvolemic Patients With End-Stage Kidney Disease on Maintenance Hemodialysis
Pulmonary hypertension (PH) is a frequent and clinically significant complication in patients with end-stage kidney disease (ESKD) undergoing maintenance hemodialysis (HD). However, PH assessment in this population is often confounded by volume overload, leading to potential overestimation and misclassification.
This prospective, multicenter observational study aims to evaluate the prevalence, phenotype, and predictors of PH in HD patients under standardized euvolemic conditions. A structured pretrial phase including volume assessment and correction will be performed prior to echocardiographic evaluation, which will be conducted after confirmation of euvolemia, post-hemodialysis or on the following day.
In participants with echocardiographic findings suggestive of PH, right heart catheterization may be performed when clinically indicated and after obtaining specific informed consent.
The study integrates clinical, biological, dialysis-related, and echocardiographic data to provide a comprehensive characterization of PH in a well-defined ESKD population.
Inclusion: Age ≥ 18 years; End-stage kidney disease on maintenance HD for ≥ 3 months; Stable clinical condition (no hospitalization in last 30 days); Able and willing to comply with study protocol; Provision of written informed consent.
Exclusion: Moderate/severe left-sided valvular disease; Active pulmonary or cardiac decompensation; Acute infection or inflammatory condition at the time of enrollment; Persistent hypervolemia after completion of the volume assessment and correction phase; Inability to undergo echocardiography or bioimpedance assessment; Inadequate echocardiographic window preventing reliable assessment.