Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training
Key facts
- Who runs it
- The Cleveland Clinic
- Where
- Cleveland, United StatesSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 52 people, planned
- Started
- 9 Dec 2025
- Expected to end
- 31 Mar 2027
- Type of study
- Interventional, 4 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Smell Training
- Record updated
- 2 July 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
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Who can take part
- Age less than 18 years-old
- Present to rhinology clinic with CRS with nasal polyps
- Sense of smell loss for any reason (other than trauma or tumor)
Who cannot take part
- Autoimmune diseases
- Ciliary disorders
- Patients < 18 years of age
- Individuals with unilateral nasal polyps
- Cystic fibrosis
- Smell loss due to tumors or trauma
Where in United States
- The Cleveland ClinicCleveland, United StatesContact: John O'NeillTaking people
About the trial
What the trial wants to find out
A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss. The impact of a 3-month olfactory training program on smell function, immunological changes, and mental health in patients with smell loss will be evaluated.
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The primary purpose of this study is to investigate tissue and blood samples to identify molecules that may be related to smell loss, ultimately aiming to develop future treatments for this condition and correlate with cognition.
The 4 groups in the trial
- Group 1: - loss of smell + CRS with nasal polyps (CRSwNP)Existing treatment, for comparison
Loss of smell + CRS with nasal polyps (CRSwNP)
Treatment: Smell Training
- Group 2: - loss of smell with no CRS/no polyps - undergo 3 months of smell trainingExisting treatment, for comparison
Loss of smell + CRS with nasal polyps (CRSwNP) - undergo 3 months of smell training
Treatment: Smell Training
- Control Group 1: - no loss of smell CRS with nasal polyps (CRSwNP)No study treatment, for comparison
No loss of smell CRS with nasal polyps (CRSwNP)
- Control Group 2: -no loss of smell / no CRS/no polypsNo study treatment, for comparison
No loss of smell / no CRS/no polyps
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 2 July 2026