MRI Scans Track Organ Fat in Teens With Severe Obesity
Studies organ fat changes in teens with severe obesity, with or without weight-loss medicine.
Plain-language title generated from the registry record
Registry title: Magnetic Resonance Imaging Assessment of Multiorgan Health in Obesity
Key facts
- Where
- Liverpool, United KingdomSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 12 and 18 years old?
Source: NCT07702825, who can take part
Where in United Kingdom
- Alder Hey Children's HospitalLiverpool, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Alder Hey Children's NHS Foundation Trust
- Trial code
- NCT07702825
- Record updated
- 14 July 2026
- Original description
The goal of this study is to quantify the body composition and organ fat distribution changes with obesity interventions in adolescents with severe obesity. The main question the investigators aim to answer is if there is improvement in organ health with weight loss intervention. The investigators will be comparing the degree of these changes between children being treated with GLP1 receptor agonists in addition to lifestyle changes and those managed with lifestyle changes alone. Participants will undergo MRI body composition at baseline and after 9 months.Read full original descriptionShow less
Impact of Weight Loss Interventions on Multiorgan Health, Detected by Quantitative MRI, in Children and Young People With Severe Obesity.
The goal of this study is to quantify the body composition and organ fat distribution changes with obesity interventions in adolescents with severe obesity. The main question the investigators aim to answer is if there is improvement in organ health with weight loss intervention. The investigators will be comparing the degree of these changes between children being treated with GLP1 receptor agonists in addition to lifestyle changes and those managed with lifestyle changes alone. Participants will undergo MRI body composition at baseline and after 9 months.
Inclusion: Age 12 to <18 years at the time of enrolment; BMI >99.6th centile or >2.67 SDS; Informed consent from parent(s) (or person with parental responsibility) and assent from the child or young person for participants aged less than 16 years (or); Informed consent from the participant if aged ≥ 16 years.
Exclusion: Any contraindications for MRI- Metal implants/claustrophobia; Previous use of GLP-1 receptor agonist; Body weight above upper limit of the scanner (>250 kilograms); Needs general anaesthesia for the MRI scanning; Refusal to consent or refusal to assent from a competent older adolescent.