Claudin 2 staining to detect gut inflammation in ulcerative colitis and Crohn disease
Compares a new tissue stain with standard scores for gut healing in IBD.
Plain-language title generated from the registry record
Registry title: Evaluation of the Accuracy of Immunostaining of Claudin 2 to Detect Active or Inactive Inflammation in Endoscopic Biopsies of IBD
Key facts
- Where
- San Donato Milanese, ItalySee the site
Where in Italy
- Gastroenterology IRCCS San Donato PoliclinicSan Donato Milanese, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- IRCCS Policlinico S. Donato
- Trial code
- NCT07710287
- Record updated
- 17 July 2026
- Original description
In view of the increasing evidence of the importance of mucosal healing as a combination of endoscopic and histologic healing, and the complexity and lack of complete agreement of the evaluation of histologic healing in IBD, the aim of this study will be to evaluate the accuracy of a new methodology, the immunostaining for Claudine 2 as compared to others standard well-accepted scoring for histologic activity in IBD. The aim is compare the accuracy of this methodology and in addition the correlation with outcomes (i.e. relapse, hospitalization, surgery).Read full original descriptionShow less
Histologic Healing in IBD: Comparison of "Standard" Scores With Expression of Claudin 2 and Impact on Outcomes
In view of the increasing evidence of the importance of mucosal healing as a combination of endoscopic and histologic healing, and the complexity and lack of complete agreement of the evaluation of histologic healing in IBD, the aim of this study will be to evaluate the accuracy of a new methodology, the immunostaining for Claudine 2 as compared to others standard well-accepted scoring for histologic activity in IBD. The aim is compare the accuracy of this methodology and in addition the correlation with outcomes (i.e. relapse, hospitalization, surgery).
Inclusion: Confirmed diagnosis of IBD.
Exclusion: Unconfirmed diagnosis of IBD.