Taking people in United KingdomNo phase

Studying blood vessel stiffness and function in people with heart failure

Observes how blood vessel stiffness and function change in adults with heart failure.

Key facts

Who runs it: Coventry University
Where: Coventry, United KingdomSee the site
Trial code: NCT07713719
Registry title: Arterial Stiffness and Endothelial Function in Heart Failure
Status: Recruiting
People taking part: 50 people, planned
Started: 18 Sept 2026
Expected to end: Jun 2028
Type of study: Observational, 2 groups
Treatments tested: Study Assessment
Record updated: 21 October 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults newly diagnosed with heart failure whose condition is stable. It studies how stiff blood vessels are and how well their lining works.

Age: 18 to 90 years
Sex: All sexes
Disease stage: New (first) diagnosis of heart failure with preserved ejection fraction or heart failure with reserved ejection fraction; heart failure must be stable in the opinion of the investigator.

Main reasons for not taking part

Cannot give informed consent
Severe symptoms, a major other illness or another diagnosis (for example cancer, severe lung disease, severe mental health problem)
Acute coronary syndrome in the last 60 days
Severe physical disability that prevents independence
Severe kidney failure

The registry criteria, word for word

Show all 2 criteriaShow less

Who can take part

Male and female ≥ 18 years old; Have a confirmed de-novo diagnosis of Heart failure with preserved ejection fraction or Heart failure with reserved ejection fraction. Common HF phenotypes (e.g., hypertension, diabetes, obesity) will be recorded as part of routine baseline data but will not influence recruitment or sampling. ; Have stable Heart failure in the opinion of the investigator; Have ability, in the opinion of the investigator, to participate in study activities; Able to provide written informed consent

Who cannot take part

• Inability to provide verbal informed consent; Presenting with severe symptoms; major co-morbidity or other alternative diagnoses (e.g., malignancy, severe respiratory disease, severe mental health problem/s); Recent acute coronary syndrome (within 60 days); Severe physical disability preventing independence; Severe renal insufficiency; Pregnancy (Present or planned); Life expectancy less than 12 months

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 90 years old?

Where in United Kingdom

University Hospitals Coventry and WarwickshireCoventry, United KingdomContact: Prithwish Banerjee, MBBS, Dip Card, MD, MRCP, FESTaking people

About the trial

What the trial wants to find out

Heart Failure (HF) is a global condition affecting at least 26 million people worldwide. Despite advances in treatment, HF patients continue to experience poor health outcomes. This study aims to improve understanding of the role of blood vessels in people with heart failure.

Read full original descriptionShow less

The study will assess how arterial stiffness (how stiff blood vessels are) and endothelial function (how well the lining of blood vessels functions) change over time and respond to treatments received as part of routine clinical care. Blood vessel function and heart performance will be assessed at three time points:

* At baseline (when Patients are first diagnosed with heart failure). * After completing 4 ± 2 weeks of heart-failure medicines prescribed to patients as part of their routine clinical care. * After completion of cardiac rehabilitation program as a part of their routine clinical care.

All assessments are non-invasive.