Tests zenagamtide tablets for weight loss in adults with excess body weight
Tests a daily tablet, zenagamtide, against a placebo in adults with obesity.
Plain-language title generated from the registry record
Registry title: AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight
Key facts
- Where
- Amarillo, Anniston, Arlington, Aurora, Birmingham, Buckley, Charleston, Chicago, City of Saint Peters, Conyers, Cumberland, Dallas, Delray Beach, Fleming Island, Fullerton, Greensboro, Gurnee, Hialeah, Honolulu, Indianapolis, Jacksonville, Las Vegas, Lomita, Miramar, Montgomery, New York, Newport News, Norman, North Charleston, Orlando, Oviedo, Raleigh, Richmond, Salisbury, Simpsonville, Skokie, Spartanburg, Walnut Creek, and Wilmington, United StatesSee the 41 sites
- Phase
- Phase 3
Where in United States
- Amarillo Medical SpecialistsAmarillo, United StatesTaking people
- Pinnacle Research Group, LLCAnniston, United StatesTaking people
- Washington Cntr Weight MgmtArlington, United StatesNot yet recruiting
- Univ of Colorado at DenverAurora, United StatesTaking people
- Univ of Alabama BirminghamBirmingham, United StatesTaking people
- Northern Pines Hlth Ctr, PCBuckley, United StatesTaking people
- Medical Uni of SC CharlestonCharleston, United StatesTaking people
- Great Lakes Clinical TrialsChicago, United StatesTaking people
- StudyMetrix Research, LLCCity of Saint Peters, United StatesTaking people
- Hope Clin Res & WellnessConyers, United StatesTaking people
- Clinical Res CollaborativeCumberland, United StatesTaking people
- North Texas Endocrine CenterDallas, United StatesTaking people
- Brain Matters ResearchDelray Beach, United StatesTaking people
- Northeast Research InstituteFleming Island, United StatesTaking people
- Providence Medical FoundationFullerton, United StatesTaking people
- Medication Mgmnt, LLC_GrnsboroGreensboro, United StatesTaking people
- Clinical Investigation Spec GurneeGurnee, United StatesTaking people
- Miguel Rebollar PAHialeah, United StatesTaking people
- East West Medical Research Institute_HonoluluHonolulu, United StatesTaking people
- Midwest Inst For Clin ResIndianapolis, United StatesNot yet recruiting
- Jacksonville Ctr Clin ResJacksonville, United StatesTaking people
- Palm Research Center IncLas Vegas, United StatesTaking people
- Torrance Clinical Research Institute, Inc.Lomita, United StatesTaking people
- South Broward Research LLCMiramar, United StatesTaking people
- Chambliss Clinical Trials, LLCMontgomery, United StatesTaking people
- Comprehensive Weight Ctrl ProgNew York, United StatesTaking people
- Health Res of Hampton RoadsNewport News, United StatesTaking people
- Lynn Institute of NormanNorman, United StatesTaking people
- Coastal Carolina Research CtrNorth Charleston, United StatesTaking people
- Clinical Neuroscience SolutionOrlando, United StatesTaking people
- Florida Institute For Clinical Research, LLCOrlando, United StatesTaking people
- Oviedo Medical Research, LLCOviedo, United StatesTaking people
- Accellacare of RaleighRaleigh, United StatesTaking people
- National Clin Res Inc.Richmond, United StatesTaking people
- Accellacare-Salisbury PMG ResSalisbury, United StatesTaking people
- Hillcrest Clinical ResearchSimpsonville, United StatesTaking people
- Endeavor HealthSkokie, United StatesTaking people
- Evanston Premier Hlthcr ResSkokie, United StatesTaking people
- Spartanburg Medical ResearchSpartanburg, United StatesTaking people
- Diablo Clinical Research, Inc.Walnut Creek, United StatesTaking people
- Accellacare and KDCILM, LLCWilmington, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Novo Nordisk A/S
- Trial code
- NCT07720271
- Record updated
- 28 September 2026
- Original description
The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.Read full original descriptionShow less
Efficacy and Safety of Once-daily Oral Zenagamtide in Participants With Obesity (AMAZE 9)
The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Inclusion: Male or female (sex at birth); Age 18 and older (both inclusive) at time of signing the informed consent.
Exclusion: Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening; History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records; Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% [48 millimoles per mole (mmol/mol)] as measured by the central laboratory at screening.