Enrolling by invitationNo phase
Journavx to Treat Pain After Thumb Basal Joint Arthroplasty
Key facts
- Who runs it
- Rothman Institute Orthopaedics
- Where
- Philadelphia, United StatesSee the site
- Trial code
- Status
- Enrolling by invitation
- People taking part
- 100 people, planned
- Started
- 21 Jul 2026
- Expected to end
- 31 Dec 2028
- Type of study
- Observational
- Treatments tested
- suzetrigine 100mg
- Acetaminophen
- Record updated
- 23 July 2026
Who can take part
- Age
- 40 years to 80 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 16 criteriaShow less
Who can take part
- Aged 40-80 years
- Undergoing thumb basal joint arthroplasty (BJA)
- Able to provide informed consent
- Willing to comply with the study procedures
Who cannot take part
- Has had prior surgery on the study hand within the last 6 months
- Use of strong or moderate CYP3A inhibitors or inducers, or medications known to interact with suzetrigine
- Currently using a prescription pain medication other study medications
- History of substance abuse or chronic opioid use
- Known allergies to acetaminophen, oxycodone, or suzetrigine
- History of kidney transplant
- History of liver failure
- Active hepatitis that can adversely influence hepatic function
- Severe renal or hepatic dysfunction
- Estimated glomerular filtration rate less than 15 ml/min/1.73m\^2
- Child-Pugh Class C
- Is currently pregnant, planning to be pregnant, or breastfeeding
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 80 years old?
Where in United States
- Rothman Orthopaedic InstitutePhiladelphia, United StatesNo longer taking part
About the trial
What the trial wants to find out
The purpose of this study is to find out how well suzetrigine, a newly FDA-approved non-opioid pain medication, works to relieve pain after thumb basal joint replacement surgery. The researchers believe that suzetrigine may provide effective pain relief during recovery without the use of opioid medications.
The group in the trial
- Participants undergoing thumb Basal Joint Replacement Surgery
Participants undergoing thumb Basal Joint Replacement Surgery receive suzetrigine (100 mg loading dose followed by 50 mg every 12 hours for 5 days) in combination with acetaminophen (Tylenol).
Treatment: suzetrigine 100mg and Acetaminophen
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- A Single-Arm Open-Label Trial Evaluating the Efficacy of Suzetrigine (Journavx) in Multimodal Postoperative Pain Management Following Thumb Basal Joint Arthroplasty
- Fit questions
- Built from NCT07723352, who can take part
- Record updated
- 23 July 2026