Studying why chronic musculoskeletal pain differs from person to person, including knee osteoarthritis
Looks at body, movement and emotional factors in adults living with chronic musculoskeletal pain.
Key facts
- Who runs it
- George Mason University
- Where
- Herndon, United StatesSee the site
- Trial code
- Registry title
- Network Modeling in Knee Osteoarthritis
- Status
- Enrolling by invitation
- People taking part
- 200 people, planned
- Started
- 13 Mar 2026
- Expected to end
- Aug 2029
- Type of study
- Observational
- Record updated
- 5 August 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with long-lasting pain around the knee. It studies how body, movement and mental and social factors link to chronic pain over time.
- Age
- 18 Years to 99 Years
- Sex
- All
- Disease stage
- Chronic pain around the knee joint for 3 months or more.
- Earlier treatment
- People who had knee surgery within the past 3 months cannot join.
Main reasons for not taking part
- Sudden (acute) pain from a knee injury or surgery within the past 3 months
- Diagnosis of lumbar radiculopathy (pinched nerve in the lower back), neuropathy or neuritis (nerve damage or inflammation)
- Bleeding disorders, taking blood thinners, recent blood transfusions, fainting spells (vasovagal syncope) or a current infection
- Pregnant women (self-reported), adults unable to consent, and prisoners
- George Mason University athletes and military members
The registry criteria, word for word
Show all 7 criteriaShow less
Who can take part
- Adults aged 18-years old or more
- Chronic pain for 3 months or more around the knee joint
Who cannot take part
- Acute pain due to knee injury or surgery within the past 3 months
- Bleeding disorders, blood thinners, recent blood transfusions, vasovagal syncope, and current infection
- Diagnosis of lumbar radiculopathy, neuropathy or neuritis
- Special populations i. Adults unable to consent ii. Pregnant women (self-reported) iii. Prisoners iv. George Mason University Athletes
- Military
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Where in United States
- Optimal Motion Physical TherapyHerndon, United StatesEnrolling by invitation
About the trial
What the trial wants to find out
This project seeks to understand inter-individual differences in chronic musculoskeletal pain (cMSKP). Our long-term objective is to develop clinically-feasible decision tools that enable whole-person assessment and management of cMSKP and guide personalized primary, secondary and tertiary prevention strategies. Our secondary objective is to understand how inter-relationships between physiological, biomechanical and psychosocial factors change over time and impact the experience of living with chronic pain.
The group in the trial
- knee pain group
adults with chronic knee pain
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Network Modeling in Knee Osteoarthritis
- Plain-language title
- Studying why chronic musculoskeletal pain differs from person to person, including knee osteoarthritisGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Fit questions
- Built from NCT07746284, who can take part
- Record updated
- 5 August 2026