Healing of the roof of the mouth after gum graft in people with obesity
Compares two healing materials after gum graft surgery in adults with obesity.
Plain-language title generated from the registry record
Registry title: Dynamics of Wound Healing in Patients With Obesity
Key facts
- Where
- Iowa City, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT07756112, who can take part
Where in United States
- University of Iowa College of Dentistry and Dental ClinicsIowa City, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Iowa
- Trial code
- NCT07756112
- Record updated
- 22 October 2026
- Original description
Healing after dental surgery can vary from person to person. This study is being done to understand how body weight (obesity vs. normal weight) may affect healing after tissue is removed from the roof of the mouth during a gum graft procedure. The study will also evaluate whether a healing material made from a participant's own blood, called platelet-rich fibrin (PRF), is comparable in quantity and quality to the standard-of-care collagen plug.Read full original descriptionShow less
Temporal Dynamics of Palatal Wound Healing With and Without Adjunctive Biologics in Patients With Obesity
Healing after dental surgery can vary from person to person. This study is being done to understand how body weight (obesity vs. normal weight) may affect healing after tissue is removed from the roof of the mouth during a gum graft procedure. The study will also evaluate whether a healing material made from a participant's own blood, called platelet-rich fibrin (PRF), is comparable in quantity and quality to the standard-of-care collagen plug.
First, participants will be classified into obese or normal weight groups. Next, participants will be randomized to receive either collagen plug or platelet-rich fibrin clot during their surgical procedure Then, participants will return for 4 visits up to 30 days from the surgery visit.
Inclusion: Be an adult who is undergoing any surgical procedure or volunteering to be part of the study; Be able and willing to give informed consent on their own; Have good oral hygiene (keep their teeth and gums clean); Have a healthy roof of the mouth with no unusual shape, disease, or injury; Not have any active illness affecting their overall health; Not have a medical condition that can slow wound healing, such as uncontrolled type 2 diabetes; Not currently pregnant; Not have received a blood transfusion in the last 3 months; For normal-weight group (BMI less than than 30 kg/m2, waist circumference less than 35 inches for women or greater than 40 inches for men) or for obesity group (BMI greater than 30 kg/m2, waist circumference greater than 35 inches for women and greater than 40 inches for men).
Exclusion: Take medications that may affect healing or require changes to the planned surgery; Have had surgery before in the area where the current procedure will be performed; Have a history of alcohol or drug abuse; Have a history of an autoimmune disease or condition; Are unable or unwilling to provide your own informed consent; Currently smoke or have smoked in the past.