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Taking people in United StatesPhase 2

A Study of SPY072 in Adults With Moderate to Severe Hidradenitis Suppurativa (The SKYLIGHT Trial)

Key facts

Who runs it
Spyre Therapeutics, Inc.
Where
Atlanta, Baton Rouge, Birmingham, Boston, Bowling Green, Coral Gables, Detroit, Durham, Indianapolis, Irvine, Las Vegas, Mill Creek, Mt. Pleasant, Murray, Nashville, New York, Oklahoma City, Owensboro, Prosper, Rogers, Smyrna, The Bronx, and Tyler, United StatesSee the 26 sitesAlso in 1 other country, 8 sites
Status
Recruiting
Phase
Phase 2
People taking part
150 people, planned
Started
Sept 2026
Expected to end
Jun 2028
Type of study
Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
Treatments tested
  • SPY072
  • Placebo
  • bimekizumab
Record updated
19 October 2026

Who can take part

Age
18 years to 75 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 7 criteriaShow less

Who can take part

  • Clinical diagnosis of Hidradenitis Suppurativa with symptoms for at least 6 months before screening
  • Hidradenitis suppurativa lesions in at least 2 distinct anatomical areas, with at least 1 area meeting Hurley Stage II or III criteria at screening and Day 1
  • Total abscess and/or inflammatory nodule count of at least 5 at screening and Day 1
  • Documented inadequate response, intolerance, or contraindication to at least 1 systemic therapy for hidradenitis suppurativa

Who cannot take part

  • Hidradenitis suppurativa lesion expected to require incision and drainage within 4 weeks before Day 1, or major hidradenitis suppurativa surgery within 12 weeks before Day 1
  • Another inflammatory or skin condition that could interfere with assessment of hidradenitis suppurativa
  • More than 20 draining tunnels at screening or Day 1

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 75 years old?

Where in United States

Also in 1 other country, 8 sites

  • Atlanta, GeorgiaHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Baton Rouge, LouisianaHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Birmingham, AlabamaHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Boston, MassachusettsHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Boston, MassachusettsHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Bowling Green, KentuckyHospital not named in the registryContact: SKYLIGHT Trial CenterTaking people
  • Coral Gables, FloridaHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Detroit, MichiganHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Durham, North CarolinaHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Indianapolis, IndianaHospital not named in the registryContact: SKYLIGHT Trial CenterTaking people
  • Irvine, CaliforniaHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Las Vegas, NevadaHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Las Vegas, NevadaHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Mill Creek, WashingtonHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Mt. Pleasant, South CarolinaHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Murray, UtahHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Nashville, TennesseeHospital not named in the registryContact: SKYLIGHT Trial CenterTaking people
  • New YorkHospital not named in the registryContact: SKYLIGHT Trial CenterTaking people
  • Oklahoma City, OklahomaHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Owensboro, KentuckyHospital not named in the registryContact: SKYLIGHT Trial CenterTaking people
  • Prosper, TexasHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Rogers, ArkansasHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Smyrna, TennesseeHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • The Bronx, New YorkHospital not named in the registryContact: SKYLIGHT Trial CenterTaking people
  • Tyler, TexasHospital not named in the registryContact: SKYLIGHT Trial CenterNot yet recruiting
  • Tyler, TexasHospital not named in the registryContact: SKYLIGHT Trial CenterTaking people

About the trial

What the trial wants to find out

This Phase 2 study will test whether the investigational medicine, SPY072, improves hidradenitis suppurativa (HS) in adults with moderate to severe disease receiving advanced standard of care treatment. About 150 participants will be assigned by chance to receive either SPY072 or placebo for 16 weeks. Participants will be followed after the treatment period to evaluate safety and how long treatment effects may last.

The 2 groups in the trial

  • SPY072 + bimekizumabTreatment being tested

    Participants receive SPY072 + bimekizumab

    Treatment: SPY072 and bimekizumab

  • Placebo + bimekizumabPlacebo, for comparison

    Participants receive matching placebo for SPY072 + bimekizumab

    Treatment: Placebo and bimekizumab

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled, Proof-of-concept Trial to Assess the Efficacy and Safety of SPY072 in Adults With Moderate to Severe Hidradenitis Suppurativa Receiving Standard of Care Treatment
Fit questions
Built from NCT07766005, who can take part
Record updated
19 October 2026