Tests brain stimulation with cognitive training for schizophrenia
Tests magnetic brain stimulation with mental exercises in adults with schizophrenia spectrum disorder.
Plain-language title generated from the registry record
Registry title: Enhancing Brain Connectivity in Schizophrenia Through Neuromodulation (Study 3)
Key facts
- Where
- Houston, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT07772349, who can take part
Where in United States
- The University of Texas Health Science Center HoustonHouston, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The University of Texas Health Science Center, Houston
- Trial code
- NCT07772349
- Record updated
- 19 August 2026
- Original description
The aim of the study is to assess the treatment effects of deep active repetitive transcranial magnetic stimulation (rTMS) with H4 coil combined with cognitive training for improving frontal white matter microstructural integrity in patients with schizophrenia spectrum disorder (SSD).Read full original descriptionShow less
Enhancing Brain Connectivity in Schizophrenia Through Neuromodulation (Study 3)
The aim of the study is to assess the treatment effects of deep active repetitive transcranial magnetic stimulation (rTMS) with H4 coil combined with cognitive training for improving frontal white matter microstructural integrity in patients with schizophrenia spectrum disorder (SSD).
Inclusion: Male and female ages between ages 18-60 years; Ability to give written informed consent (age 18 or above); Diagnosed with schizophrenia-spectrum disorder and Evaluation to Sign Consent (ESC) above 10.
Exclusion: Significant alcohol or other drug use (substance abuse within 1 month or substance dependence history within 6 months and having substance usage within 1 month) other than nicotine or marijuana dependence; Cannot refrain from using alcohol and/or marijuana 24 hours or more prior to experiments; Any history of seizures; Any acute and unstable major medical illnesses that may affect normal brain functioning. Examples of these conditions include, but not limited to, recent stroke, seizure, history of significant head trauma, CNS infection or tumor, other significant brain neurological conditions (As this is a study of medical comorbidity, most medical conditions, once stable, are not exclusion criteria); Taking > 400 mg clozapine/day and not on anti-seizure medication(s) with sufficient dose; A history of thrombosis, family history of thrombosis, or medical conditions that may lead to a hypercoagulable state (increased chance to develop blood clots); History of head injury with loss of consciousness over 10 minutes; history of brain surgery; For MRI, unable to undergo MRI scanning due to metallic devices or objects (cardiac pacemaker or neurostimulator, some artificial joints, metal pins, surgical clips, or other implanted metal parts) or claustrophobic to the scanner; Inability to sign informed consent; Failed TMS screening questionnaire; Woman who is pregnant (child-bearing potential but not on contraceptive and missing menstrual period; or by self-report; or by positive urine pregnancy test); Students and employees currently involved with our lab (lab employees and personnel will be excluded from the study to avoid possible coercion or possible appearance of coercion, or chance of breach of privacy and confidentiality).