Comparing Devices That Measure Body Fat and Lean Mass in Adults
Compares body composition measurements from different devices in healthy adults, including people with overweight.
Plain-language title generated from the registry record
Registry title: Redefining Evaluation of Adiposity and Leanness: Broadening Objective Diagnostics for Obesity
Key facts
- Where
- Boston, Menlo Park, and Phoenix, United StatesSee the 3 sites
Where in United States
- Exponent BostonBoston, United StatesTaking people
- Exponent Menlo ParkMenlo Park, United StatesTaking people
- Exponent PhoenixPhoenix, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Foundation for the National Institutes of Health
- Trial code
- NCT07776678
- Record updated
- 26 October 2026
- Original description
The purpose of this study is to evaluate body composition across a variety of medical, professional, and commercial devices, including: bioelectrical impedance analysis (BIA) devices, 3-dimensional optical imaging (3DO), manual anthropometry measurements, dual-energy X-ray absorptiometry (DXA), magnetic resonance imaging (MRI), and blood tests. The secondary study purpose is to compare body composition measurements from BIA devices, 3DO, and manual anthropometry measurements within a 1-week period for a subset of the study population.Read full original descriptionShow less
Redefining Evaluation of Adiposity and Leanness: Broadening Objective Diagnostics for Obesity (REAL-BODY)
The purpose of this study is to evaluate body composition across a variety of medical, professional, and commercial devices, including: bioelectrical impedance analysis (BIA) devices, 3-dimensional optical imaging (3DO), manual anthropometry measurements, dual-energy X-ray absorptiometry (DXA), magnetic resonance imaging (MRI), and blood tests. The secondary study purpose is to compare body composition measurements from BIA devices, 3DO, and manual anthropometry measurements within a 1-week period for a subset of the study population.
The study plans to enroll 300 healthy (having no life-threatening conditions or diseases; male and female) participants, 18 years of age or older.
Inclusion: Being willing to provide written informed consent prior to participation Being willing to complete the study visits and comply with the study procedures; Being willing to travel to the various study locations for On-site, DXA, MRI, and Phlebotomy visits; Being willing to change into appropriate form-fitting clothing for 3DO assessments and/or appropriate gowns for DXA and MRI imaging; Must have a BMI within the range of 18.5 - 45 kg/m2; Being willing to refrain from all food, drink, and substances for 8 hours prior to the On-site visit(s) and phlebotomy visit; Being willing to refrain from all food, drink, and substances for 4 hours prior to the DXA and MRI scan visits; Being willing to refrain from any exercise or vigorous physical activity for 24 hours prior to all visits; Stable weight (no more than 5 kg change) for 3 months prior to screening; If recruited in the Phoenix, AZ area, participants must be willing to drive yourself to the Phoenix Office location for the On-site Visits 1 and 2 (if applicable) located at the Exponent Phoenix Office.
Exclusion: Having medical implants, such as a pacemaker or metal joint replacements, or other metal implants contraindicated for MRI; Cosmetic implants, such as breast implants; Prior amputation or major body-altering surgery that could invalidate body composition estimates; Having claustrophobia or a history of claustrophobia; Known HIV infection; Known hydration abnormality (e.g., significant edema, end-stage renal disease, end-stage liver disease); Severe illness or life-threatening conditions such as end-stage kidney, liver, lung disease, NYHA III-IV heart failure, or active malignancy; Being pregnant or attempting to become pregnant; Having a height greater than DXA scanning limit (77 inches); Having a body weight greater than indicated for the equipment (400 lbs); Known Lipodystrophy.