Following adults with past COVID-19 to study persistent symptoms
Studies how often Long COVID occurs and who keeps symptoms over time.
Plain-language title generated from the registry record
Registry title: Long-Term Study of COVID-19 Infection and Long COVID
Key facts
- Where
- Chapel Hill, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07781501, who can take part
Where in United States
- University of North CarolinaChapel Hill, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of North Carolina, Chapel Hill
- Trial code
- NCT07781501
- Record updated
- 28 September 2026
- Original description
This study will examine how common Long COVID is and how symptoms may persist over time in people who have previously had COVID-19. Researchers will collect information about participants' health and symptoms through questionnaires and may collect saliva and other non-invasive oral samples. The study will also examine biological factors in these samples that may be associated with persistent symptoms. The goal is to better understand why some people develop Long COVID and identify factors that may help predict who is more likely to experience persistent symptoms.Read full original descriptionShow less
Longitudinal Study of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Post-Acute Sequelae of COVID-19 (PASC)
This study will examine how common Long COVID is and how symptoms may persist over time in people who have previously had COVID-19. Researchers will collect information about participants' health and symptoms through questionnaires and may collect saliva and other non-invasive oral samples. The study will also examine biological factors in these samples that may be associated with persistent symptoms. The goal is to better understand why some people develop Long COVID and identify factors that may help predict who is more likely to experience persistent symptoms.
Inclusion: Age 18 to 75 years; Previous laboratory-confirmed SARS-CoV-2 infection; Willing and able to provide informed consent; Able to complete study questionnaires and study procedures.
Exclusion: Oral viral or bacterial infection within the previous 30 days; Active alcohol or drug abuse; Current severe periodontal disease with bleeding gums; Current oral herpes flare, aphthous ulcer, or oral candidiasis (thrush); Medical or genetic syndrome or developmental delay that would prevent completion of study procedures or questionnaires; Dry mouth that would prevent adequate saliva collection.