App-Based Strength Training for Midlife Women Taking GLP-1 Weight-Loss Medication
Tests an app-based strength training program in women taking GLP-1 medication for weight loss.
Key facts
- Who runs it
- Louisiana State University and A&M College
- Where
- Baton Rouge, United StatesSee the site
- Trial code
- Registry title
- Digital Resistance Training for Midlife Women Using GLP-1
- Status
- Not yet recruiting
- People taking part
- 15 people, planned
- Started
- 1 Nov 2026
- Expected to end
- 30 Jun 2027
- Type of study
- Interventional
- Treatments tested
- PLAN-RT 1.0
- Record updated
- 26 August 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women who recently started GLP-1 medication for weight loss and do not do regular strength training. It tests a 12-week app-based strength program.
- Age
- 40 to 54 years in the inclusion criteria (the registry lists 40 to 59 years).
- Sex
- Women only.
- Disease stage
- Body mass index (BMI) of 27 kg/m² or more.
- Earlier treatment
- Must have started GLP-1 receptor agonist (GLP-1RA) therapy within the past 6 months. Must not have done regular resistance training in the past month.
Main reasons for not taking part
- Plans to stop or substantially change GLP-1RA therapy during the 12 weeks
- Muscle, bone or joint injury or surgery in the past 6 months that rules out strength training
- Unstable heart disease or a heart event in the past 6 months
- Currently pregnant or planning to become pregnant during the study
- Taking part in another medication, behavior, weight management or chronic disease program
The registry criteria, word for word
Show all 15 criteriaShow less
Who can take part
- Female, age 40 to 54 years
- Recently initiated GLP-1 receptor agonist (GLP-1RA) therapy within the past 6 months
- Body mass index (BMI) ≥27 kg/m²
- Not currently participating in regular resistance training (self-reported absence of regular resistance training during the previous month)
- Able to stand, sit, and perform bodyweight movements without assistive devices
- Owns a compatible smartphone (iOS or Android) with cellular or Wi-Fi access and is willing to use study applications
- Able to read, understand, and provide informed consent in English
- Willing and able to attend required in-person study visits
Who cannot take part
- Plans to discontinue GLP-1RA therapy or substantially modify treatment during the 12-week study period
- Self-reported musculoskeletal injury, orthopedic limitation, or surgery within the previous 6 months that would contraindicate resistance training participation
- Self-reported unstable cardiovascular disease or cardiac event within the previous 6 months
- Active eating disorder or psychiatric condition that may interfere with study participation
- Current participation in another pharmacological, behavioral, weight management, or chronic disease management program that could confound study outcomes
- Currently pregnant or planning to become pregnant during the study period
- Unable to use smartphone applications required for the intervention
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 59 years old?
Where in United States
- Louisiana State University School of KinesiologyBaton Rouge, United StatesContact: Shiyu Li, Ph.D.Not yet recruiting
About the trial
What the trial wants to find out
The goal of PLAN-RT 1.0 to learn if a 12-week app-based strength training program can help midlife women build and stick with a regular strength training routine while they are taking GLP-1 medication for weight loss. PLAN-RT 1.0 targets women ages 40 to 59 who were not regularly exercising before starting GLP-1 medication.
Read full original descriptionShow less
The main questions this study aims to answer are: (1) Is the PLAN-RT 1.0 program feasible and acceptable to participants (based on how many people join, stay in the study, and use the program)? (2) Does the program lead to early changes in muscle strength, body composition, physical function, and exercise habits?
The group in the trial
- PLAN-RT 1.0Treatment being tested
Participants will receive PLAN-RT 1.0, a 12-week digitally delivered resistance training intervention designed for physically inactive midlife women (ages 40-59 years) who have recently initiated GLP-1 receptor agonist (GLP-1RA) therapy. The intervention combines a Fitbit Versa smartwatch, LIT AXIS™ smart resistance band, and smartphone applications integrated through the Pathverse platform to support resistance training participation. Participants will receive exercise instruction and form guidance, personalized resistance training goal setting, implementation intention-based action planning, contextual prompts delivered through smartwatch notifications, self-monitoring of exercise behavior, and feedback on goal attainment. Resistance training activities include bodyweight and resistance band exercises performed according to a structured progressive program over 12 weeks.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Developing a Scalable Digital Resistance Training Intervention to Preserve Muscle Function in Midlife Women Receiving GLP-1 Therapy
- Plain-language title
- App-Based Strength Training for Midlife Women Taking GLP-1 Weight-Loss MedicationGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07787533, who can take part
- Record updated
- 26 August 2026