Taking people in United StatesPhase 3
Orforglipron for adults who are overweight and at risk of obesity-related health problems
Tests orforglipron against placebo in adults who are overweight.
Plain-language title generated from the registry record
Registry title: A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity
Key facts
- Where
- Anniston, Atlanta, Austin, Baton Rouge, Bay City, Birmingham, Boca Raton, Boston, Brownsville, Charleston, Chicago, Columbia, Columbus, Conyers, Corvallis, Dallas, Dalton, Danville, Decatur, El Paso, Euless, Fargo, Greensboro, Hartsdale, Houston, Idaho Falls, Kingwood, Knoxville, Lake Forest, Las Vegas, Long Beach, Long Island City, Longview, Los Angeles, Louisville, Maplewood, Mauldin, Media, Meridian, Mesa, Miami, Monroe, Morehead City, Nashville, New Haven, Ocala, Orlando, Oviedo, Palm Springs, Pelham, Phoenix, Reno, Richmond, Riverside, Rochester, Sacramento, San Antonio, San Ramon, Shavano Park, Southfield, Springfield, St. Petersburg, Sunrise, Topeka, Troy, Tucson, Tulsa, Tyler, Walnut Creek, Warren Township, Waterbury, West Chester, West Des Moines, and Wilmington, United StatesSee the 80 sites
- Phase
- Phase 3
Where in United States
- Pinnacle Research Group, LLCAnniston, United StatesTaking people
- SKY Clinical Research Network Group-BrownAtlanta, United StatesTaking people
- IMA Clinical Research AustinAustin, United StatesTaking people
- Pennington Biomedical Research CenterBaton Rouge, United StatesTaking people
- Great Lakes Research Group, Inc.Bay City, United StatesTaking people
- Central Research AssociatesBirmingham, United StatesTaking people
- Excel Medical Clinical TrialsBoca Raton, United StatesTaking people
- Brigham and Women's Hospital Diabetes ProgramBoston, United StatesTaking people
- Headlands Horizons, LLC dba Headlands Research-BrownsvilleBrownsville, United StatesTaking people
- CAMC Institute for Academic MedicineCharleston, United StatesNot yet recruiting
- Great Lakes Clinical Trials - RavenswoodChicago, United StatesTaking people
- Centennial Medical GroupColumbia, United StatesTaking people
- Remington Davis, Inc.Columbus, United StatesTaking people
- HOPE Clinical Research & WellnessConyers, United StatesTaking people
- The Corvallis Clinic, P.C.Corvallis, United StatesTaking people
- Cedar Health Research - Texas Native HealthDallas, United StatesTaking people
- Care Access - Dalton WalmartDalton, United StatesTaking people
- Sovah Clinical Research-River DistrictDanville, United StatesNot yet recruiting
- Care Access - DecaturDecatur, United StatesTaking people
- Headlands Research-El PasoEl Paso, United StatesTaking people
- Cedar Health Research - EulessEuless, United StatesTaking people
- Lillestol ResearchFargo, United StatesTaking people
- Medication ManagementGreensboro, United StatesTaking people
- Drug Trials AmericaHartsdale, United StatesTaking people
- Biopharma Informatic, LLCHouston, United StatesTaking people
- Care Access - Houston - Clinical Trials Center by Walmart & Care AccessHouston, United StatesTaking people
- Family First Medical CenterIdaho Falls, United StatesTaking people
- Activian Clinical ResearchKingwood, United StatesTaking people
- Frontier Clinical Research, LLCKingwood, United StatesTaking people
- New Phase Research And DevelopmentKnoxville, United StatesTaking people
- Orange County Research CenterLake Forest, United StatesTaking people
- M3 Wake Research - Las Vegas CimarronLas Vegas, United StatesTaking people
- Healthy Brain ClinicLong Beach, United StatesTaking people
- NYC Research Inc.Long Island City, United StatesTaking people
- DCOL Center for Clinical ResearchLongview, United StatesTaking people
- Los Angeles Institute for Metabolic ResearchLos Angeles, United StatesTaking people
- Monroe Biomedical Research - LouisvilleLouisville, United StatesNot yet recruiting
- Headlands Research-Twin CitiesMaplewood, United StatesTaking people
- Care Access - MauldinMauldin, United StatesTaking people
- Clinical Renal Associates Ltd.Media, United StatesTaking people
- Solaris Clinical ResearchMeridian, United StatesTaking people
- Care Access - 801 South Power Road, MesaMesa, United StatesTaking people
- Flourish Research Acquisition, LLC dba Flourish Research - North MiamiMiami, United StatesTaking people
- New Age Medical Research CorporationMiami, United StatesTaking people
- IMA Clinical Research Monroe-MainMonroe, United StatesTaking people
- Monroe Biomedical ResearchMonroe, United StatesNot yet recruiting
- West Clinical ResearchMorehead City, United StatesTaking people
- Clinical Research Associates, Inc.Nashville, United StatesTaking people
- Yale University School Of MedicineNew Haven, United StatesTaking people
- Renstar Medical ResearchOcala, United StatesTaking people
- Headlands Research OrlandoOrlando, United StatesTaking people
- Oviedo Medical ResearchOviedo, United StatesTaking people
- Desert Oasis Healthcare Medical GroupPalm Springs, United StatesTaking people
- Cahaba Research - PelhamPelham, United StatesTaking people
- Absolute Clinical ResearchPhoenix, United StatesNot yet recruiting
- Renascor Clinical ResearchReno, United StatesTaking people
- Clinical Research Partners, LLCRichmond, United StatesTaking people
- Artemis Institute for Clinical ResearchRiverside, United StatesTaking people
- Riverside ClinicalRiverside, United StatesTaking people
- Rochester Clinical Research, LLCRochester, United StatesTaking people
- Headlands Research- SacramentoSacramento, United StatesTaking people
- IMA Clinical Research San AntonioSan Antonio, United StatesTaking people
- VIP TrialsSan Antonio, United StatesTaking people
- Norcal Endocrinology & Internal MedicineSan Ramon, United StatesTaking people
- Consano Clinical Research, LLCShavano Park, United StatesTaking people
- Great Lakes Research InstituteSouthfield, United StatesTaking people
- Clinvest Headlands LLCSpringfield, United StatesTaking people
- Care Access - St. PetersburgSt. Petersburg, United StatesTaking people
- Precision Clinical ResearchSunrise, United StatesTaking people
- Cotton O'Neil Clinical Research CenterTopeka, United StatesNot yet recruiting
- Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroy, United StatesTaking people
- Synexus Clinical Research US, Inc./Orange Grove Family PracticeTucson, United StatesTaking people
- Central States ResearchTulsa, United StatesTaking people
- Care Access - Tyler - Clinical Trials Center by Walmart & Care AccessTyler, United StatesTaking people
- Diablo Clinical Research, Inc.Walnut Creek, United StatesTaking people
- IMA Clinical Research WarrenWarren Township, United StatesTaking people
- Chase Medical Research, LLCWaterbury, United StatesTaking people
- Suburban Research AssociatesWest Chester, United StatesTaking people
- Iowa Diabetes and Endocrinology Research CenterWest Des Moines, United StatesTaking people
- Trial Management Associates - Wilmington - Floral ParkwayWilmington, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Eli Lilly and Company
- Trial code
- NCT07794579EU 2026-526175-35-00
- Record updated
- 5 November 2026
- Original description
This study will evaluate the efficacy and safety of orforglipron in participants with overweight and assess whether it helps reduce the future risk of obesity-related conditions, including type 2 diabetes, hypertension, and dyslipidemia, and progression to class 1 obesity.Read full original descriptionShow less
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Once-Daily Oral Orforglipron Compared With Placebo in Individuals With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity
This study will evaluate the efficacy and safety of orforglipron in participants with overweight and assess whether it helps reduce the future risk of obesity-related conditions, including type 2 diabetes, hypertension, and dyslipidemia, and progression to class 1 obesity.
Inclusion: Have an increased waist-to-height ratio of ≥0.5; Have at least one pre-obesity-related complication (prediabetes, prehypertension, predyslipidemia); Have at least one unsuccessful attempt to reduce body weight based on diet and exercise; Have a BMI greater than or equal to 25 to less than or equal to 29.9 kg/m2 or equivalent-/region-specific overweight thresholds.
Exclusion: Do not have a stable body weight within 90 days before screening; Have taken medications for weight loss, including over-the counter medications or alternative therapies, within 180 days prior to screening; Have a prior or planned surgical treatment or procedure for obesity; Have type 1 diabetes, type 2 diabetes, or any other type of diabetes; Have a documented obesity diagnosis or self-reported history of BMI ≥30 kg/m² (or an equivalent region-specific threshold); Have hypertension or history of hypertension; Have dyslipidemia or history of dyslipidemia.