Comparing Two Imaging Technologies With Standard Colonoscopy to Find and Classify Colorectal Polyps
Compares VIST and SFI imaging with white light colonoscopy for finding colorectal lesions.
Plain-language title generated from the registry record
Registry title: Evaluation of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for Detection and Optical Characterization of Colorectal Lesions: A Prospective Randomized Controlled Study
Key facts
- Where
- Porto Alegre, BrazilSee the site
Where in Brazil
- Hospital Sao Lucas da PUCRSPorto Alegre, BrazilNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Alexandre Vontobel Padoin
- Trial code
- NCT07797361
- Record updated
- 1 September 2026
- Original description
This prospective randomized controlled study aims to evaluate the diagnostic accuracy of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for detection and optical characterization of colorectal lesions during colonoscopy. The performance of VIST and SFI will be compared with high-definition white light endoscopy (WLE), using histopathology as the reference standard and established endoscopic classifications (Paris, Kudo, and JNET). The study will also assess adenoma detection rate, serrated lesion detection, inter- and intraobserver agreement, and procedure-related metrics.Read full original descriptionShow less
Evaluation of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for Detection and Optical Characterization of Colorectal Lesions: A Prospective Randomized Controlled Study (INSIGHT Study)
This prospective randomized controlled study aims to evaluate the diagnostic accuracy of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for detection and optical characterization of colorectal lesions during colonoscopy. The performance of VIST and SFI will be compared with high-definition white light endoscopy (WLE), using histopathology as the reference standard and established endoscopic classifications (Paris, Kudo, and JNET). The study will also assess adenoma detection rate, serrated lesion detection, inter- and intraobserver agreement, and procedure-related metrics.
Inclusion: Age ≥ 18 years; Undergoing screening or surveillance colonoscopy; Adequate bowel preparation (Boston Bowel Preparation Scale ≥6, with ≥2 per segment); Ability to understand and sign informed consent.
Exclusion: Prior colorectal resection; History of inflammatory bowel disease (Crohn's disease or ulcerative colitis); Colorectal stenosis preventing scope progression; Pregnancy or breastfeeding; Inadequate bowel preparation; Clinical contraindication to colonoscopy.