Colorectal cancer trials in Brazil

In Brazil 27 Also abroad 1930

27 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Where
Barretos, Florianópolis, Ijuí, Passo Fundo, Porto Alegre, Recife, São José do Rio Preto, São José dos Campos, São Paulo
Age
18 years and over
People
477 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06997497 · EU 2024-517232-22-00
Phase 3Taking people
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Where
Barretos, Caxias do Sul, Jaú, Porto Alegre, Salvador, Santa Maria, São José do Rio Preto, São Paulo, Vitória
Age
18 years and over
People
1,000 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06662786 · EU 2024-513852-13-00
Phase 3Taking people
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
Where
Barretos, Caxias do Sul, Jaú, Porto Alegre, Salvador, São José do Rio Preto, São Paulo, Vitória
Age
18 years and over
People
700 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06750094 · EU 2024-513853-66-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Where
Barretos, Blumenau, Curitiba, Ijuí, Itajaí, Lajeado, Natal, Porto Alegre, Ribeirão Preto, Salvador, São Caetano do Sul, Sao Jose Rio Preto, São Paulo
Age
18 years and over
People
700 worldwide
Run by
Incyte Corporation
See details and how to joinNCT07284849 · EU 2025-523735-19-00
Phase 2Taking people
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
Where
Barretos, Ijuí, Salvador, São José do Rio Preto, São Paulo
Age
18 years and over
People
390 worldwide
Run by
AbbVie
See details and how to joinNCT06820463 · EU 2024-512981-33-00
Phase 1/2Taking people
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Where
Barretos, Florianópolis, Jaú, Porto Alegre
Age
18 years and over
People
680 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06330064 · EU 2023-509632-26-00
Phase 2/3Taking people
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Where
Barretos, Curitiba, Natal, Porto Alegre, Santa Cruz do Sul, São José do Rio Preto, São Paulo
Age
18 years and over
People
990 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07221357 · EU 2025-523224-45-00
Phase 2Taking people
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
Where
Bauru, Goiânia, Ijuí, Jaú, Pelotas, São Paulo, Vitória
Age
18 years and over
People
140 worldwide
Run by
Vividion Therapeutics, Inc.
See details and how to joinNCT07811193 · EU 2026-525507-26-00
Phase 1/2Taking people
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
Where
Porto Alegre, São Paulo, Teresina
Age
18 years and over
People
346 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06885034
Phase 3Taking people
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Where
Porto Alegre, Recife, Rio de Janeiro, São Caetano do Sul, São Paulo
Age
18 years and over
People
800 worldwide
Run by
Pfizer
See details and how to joinNCT07222800 · EU 2025-523521-18-00
Phase 1Taking people
Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
Where
Natal, Porto Alegre, São Paulo, Sorocaba
Age
18 years and over
People
392 worldwide
Run by
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
See details and how to joinNCT06625775 · EU 2024-519445-29-00
Phase 3Taking people
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Where
Barretos, Brasília, Cachoeiro de Itapemirim, Ijuí, Itajaí, Natal, Porto Alegre, Rio de Janeiro, São José do Rio Preto, São Paulo, Teresina
Age
18 years and over
People
450 worldwide
Run by
Amgen
See details and how to joinNCT06252649
No phaseNot yet taking people in Brazil
Evaluation of Versatile Intelligent Staining Technology (VIST) and Spectral Flexible Imaging (SFI) for Detection and Optical Characterization of Colorectal Lesions: A Prospective Randomized Controlled Study
Where
Porto Alegre
Age
18 years and over
People
990
Run by
Alexandre Vontobel Padoin
See details and how to joinNCT07797361
Phase 3Taking people
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Where
Barra da Tijuca, Barretos, Curitiba, Jaú, Porto Alegre, Rio de Janeiro, Santo André, São José do Rio Preto, São Paulo
Age
18 years and over
People
400 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT05253651 · EU 2024-514180-25-00
No phaseTaking people
Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal Lesions
Where
São Paulo
Age
18 years and over
People
1,000
Run by
Instituto do Cancer do Estado de São Paulo
See details and how to joinNCT07066046
No phaseTaking people
Real World Multicenter National Study to Evaluate the Effectiveness and Safety of Biosimilar Bevacizumab Elovie
Where
Campinas, Curitiba, Jaraguá do Sul, Londrina, Porto Alegre, Recife, Santo Ângelo, São Caetano do Sul, São José dos Campos, São Paulo, Teresina, Vitória
Age
18 years and over
People
133
Run by
Libbs Farmacêutica LTDA
See details and how to joinNCT06808685
No phaseTaking people
Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimally Invasive Left-Sided Colorectal Resection (BAPTAP)
Where
Belo Horizonte
Age
18 years to 80 years
People
140
Run by
Faculdade de Ciências Médicas de Minas Gerais
See details and how to joinNCT07388953
Phase 3Taking people
Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
Where
Barretos, Belém, Campo Grande, Lages, Natal, Porto Alegre, Salvador, São José do Rio Preto, São Paulo, Teresina, Vitória
Age
18 years and over
People
892 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT05855200 · EU 2023-503265-27-00
Phase 4Taking people
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
Where
Florianópolis, Natal, Passo Fundo, Porto Alegre, São Bernardo do Campo, São José do Rio Preto, São Paulo, Taguatinga
Age
18 years to 64 years
People
2,076 worldwide
Run by
Guerbet
See details and how to joinNCT04373564
No phaseTaking people
Study to Evaluate the Use of Surgical Gloves for the Prevention of Oxaliplatin-Induced Peripheral Neuropathy
Where
São Paulo
Age
18 years and over
People
84
Run by
AC Camargo Cancer Center
See details and how to joinNCT07285356
No phaseTaking people
Use of Preoperative Postbiotic Supplementation in Colorectal Cancer Surgery
Where
São Paulo
Age
18 years and over
People
164
Run by
AC Camargo Cancer Center
See details and how to joinNCT07268846
No phaseEnrolling by invitation
Development of Polygenic Risk Scores in Colon Cancer Patients Through the Study of Ancestry and Diversity in Genetic Maps of the Brazilian Population - ORIGEM Project
Where
Brasília, Curitiba, Fortaleza, Recife, Rio de Janeiro, Salvador, São Paulo
Age
18 years and over
People
500
Run by
D'Or Institute for Research and Education
See details and how to joinNCT06917794
Phase 2Taking people
Intestinal Microbiome Modulation With Antibiotics in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer
Where
São Paulo
Age
18 years and over
People
100
Run by
AC Camargo Cancer Center
See details and how to joinNCT06793137
No phaseNot yet taking people in Brazil
Proteomic Analysis of Patients Undergoing Bariatric Surgery
Where
Recife
Age
18 years and over
People
103
Run by
Universidade Federal de Pernambuco
See details and how to joinNCT06787807
Phase 2Taking people
Stereotactic Body Radiation Therapy (SBRT) for Unresectable Liver Metastases
Where
São Paulo
Age
18 years and over
People
43
Run by
University of Sao Paulo
See details and how to joinNCT02185443