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Temporal Interference Stimulation Combined With Tai Chi for Mild Cognitive Impairment

Key facts

Who runs it
Shanghai University of Sport
Where
China1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
120 people, planned
Started
27 Aug 2026
Expected to end
1 Apr 2027
Type of study
Interventional, 2 groups
Treatments tested
  • Active Transcranial Temporal Interference Stimulation
  • Placebo Transcranial Temporal Interference Stimulation
  • Tai Chi Training
Record updated
9 November 2026

Who can take part

Age
60 years to 80 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 16 criteriaShow less

Who can take part

  • Age 60-80 years
  • Community-dwelling
  • Montreal Cognitive Assessment (MoCA) score < 26
  • Clinical Dementia Rating (CDR) score = 0.5
  • Activities of Daily Living (ADL) score < 26 (largely intact daily function)
  • Does not meet criteria for dementia diagnosis (based on DSM-5 or NIA-AA criteria)
  • No contraindications for MRI examination (no metallic implants, no claustrophobia)
  • Able to provide written informed consent

Who cannot take part

  • Previous deep brain stimulation or electroconvulsive therapy within 6 months
  • Concurrent participation in another interventional clinical trial
  • Neurological conditions that may cause cognitive decline (e.g., cerebrovascular disease, encephalitis, Parkinson's disease, Huntington's disease)
  • Severe depression (Geriatric Depression Scale > 10) or other major psychiatric disorders
  • History of seizures or epilepsy
  • Contraindications for non-invasive brain stimulation: electronic or ferromagnetic implants, non-MRI compatible metal implants, history of seizures, pregnancy
  • Severe visual, auditory, or language impairments preventing completion of neuropsychological assessments
  • Alcohol or substance dependence

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 60 and 80 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

This study aims to evaluate whether individualized hippocampal transcranial temporal interference stimulation (tTIS) combined with Tai Chi training can improve cognitive function and dual-task performance in individuals with mild cognitive impairment. Participants will be randomly assigned to receive either active or sham individualized tTIS combined with Tai Chi training for 8 weeks. The study will also investigate changes in brain structure and function using neuroimaging and assess whether the intervention effects are maintained during follow-up.

The 2 groups in the trial

  • Active tTIS Combined With Tai ChiTreatment being tested

    Participants will receive active individualized hippocampal transcranial temporal interference stimulation (tTIS) combined with Tai Chi training for 8 weeks, three sessions per week. Each tTIS session will last 20 minutes and each Tai Chi session approximately 60 minutes.

    Treatment: Active Transcranial Temporal Interference Stimulation and Tai Chi Training

  • Placebo tTIS Combined With Tai ChiTreatment being tested

    Participants will receive sham individualized hippocampal transcranial temporal interference stimulation (tTIS) combined with the same Tai Chi training for 8 weeks, three sessions per week. Placebo (sham) stimulation will use the same electrode configuration and session duration as active stimulation but without effective stimulation during the main stimulation period.

    Treatment: Placebo Transcranial Temporal Interference Stimulation and Tai Chi Training

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Effects of Transcranial Temporal Interference Stimulation Combined With Tai Chi Training on Cognitive Function, Dual-Task Performance, and Neuroimaging Mechanisms in Individuals With Mild Cognitive Impairment
Fit questions
Built from NCT07799584, who can take part
Record updated
9 November 2026